INT164401

Context Info Confidence 0.52 First Reported 2009 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.47 Pain Relevance 0

cell differentiation (CNTF) cytosol (CNTF) signal transduction (CNTF) extracellular space (CNTF) growth (CNTF) nucleus (CNTF)

Anatomy Link Frequency spinal 2 CSF 2 CNTF (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropathic pain 8 50.00 painful pain 4 50.00 Pain 6 10.00 Nerve growth factor 2 5.00

Disease Link Frequency Relevance Heat Hydrocephalus 2 86.52 Nociception 4 85.84 Neuropathic Pain 8 83.92 Normal Pressure Hydrocephalus 2 50.00 Pain 4 5.00 Syndrome 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.

Neg (not) Regulation (controls) of Gene_expression (levels) of CNTF in spinal

1) Confidence 0.52 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.22 Pain Relevance 0

RESULTS: The CSF concentrations of CNTF, BDNF, and NGF did not differ between the 3 patient cohorts.

Neg (not) Regulation (differ) of Gene_expression (concentrations) of CNTF in CSF

2) Confidence 0.44 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.26 Pain Relevance 0

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