INT164425

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.46
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
conjunctiva 2
central nervous system 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 58 100.00 Very High Very High Very High
Central nervous system 6 98.70 Very High Very High Very High
gABA 59 98.12 Very High Very High Very High
Transcranial magnetic stimulation 50 98.04 Very High Very High Very High
Neuropeptide 30 94.68 High High
GABAergic 9 93.72 High High
Inflammatory mediators 1 93.68 High High
Thalamus 2 92.72 High High
cytokine 4 92.60 High High
Calcitonin gene-related peptide 11 89.68 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 99.80 Very High Very High Very High
Nervous System Malformation 2 98.98 Very High Very High Very High
Conjunctiva Disease 10 97.72 Very High Very High Very High
Tooth Loss 13 95.92 Very High Very High Very High
Hypersensitivity 38 95.68 Very High Very High Very High
Disease 19 95.32 Very High Very High Very High
INFLAMMATION 7 93.28 High High
Disorders Of The Lacrimal System 3 86.96 High High
Conjunctivitis 4 81.20 Quite High
Increased Venous Pressure Under Development 7 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients in the SpA groups had higher percentages in onset <40 years, insidious onset, morning stiffness, and affected for >3 months compared with those in other LBP groups.
Regulation (affected) of Gene_expression (groups) of SpA
1) Confidence 0.44 Published 2009 Journal Scand. J. Rheumatol. Section Body Doc Link 19922021 Disease Relevance 0.06 Pain Relevance 0
As it is known that agenesis of the corpus callosum may be associated with a variety of central nervous system abnormalities, it is possible that these abnormalities are also involved in SP prolongation.
Spec (possible) Regulation (involved) of Gene_expression (prolongation) of SP in central nervous system associated with congenital anomalies, nervous system malformation and central nervous system
2) Confidence 0.34 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.26 Pain Relevance 0.29
Our data support this conclusion, as only SP duration was affected in our patient population, presumably through GABA-b receptors, whereas short ICI was normal.
Regulation (affected) of Gene_expression (duration) of SP associated with gaba
3) Confidence 0.34 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.13 Pain Relevance 0.46
In line with this hypothesis, an increase of SP tear and plasma levels and an altered VIP and SP expression in the conjunctiva have been described in patients with vernal keratoconjunctivitis (VKC), a severe ocular allergic disease mainly affecting young boys [23-25].
Regulation (altered) of Gene_expression (expression) of SP in conjunctiva associated with conjunctiva disease, hypersensitivity, disease and substance p
4) Confidence 0.07 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.49 Pain Relevance 0.50
Approximately 61% of D12 cells were positive for SP expression.
Regulation (positive) of Gene_expression (expression) of SP associated with substance p
5) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.07 Pain Relevance 0.55
The estimates for the area under the ROC curve obtained for each of the dental health outcomes studied and the total OHIP-Sp score ranged between 0.56 for having CAL ?
Regulation (ranged) of Gene_expression (score) of OHIP-Sp
6) Confidence 0.02 Published 2006 Journal BMC Oral Health Section Body Doc Link PMC1534011 Disease Relevance 0.43 Pain Relevance 0.10

General Comments

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