INT16445

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 60
Total Number 61
Disease Relevance 44.46
Pain Relevance 19.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
macrophages 4
monocyte 4
reservoir 2
chondrocyte 1
gingiva 1
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 787 100.00 Very High Very High Very High
chemokine 97 100.00 Very High Very High Very High
cINOD 67 99.84 Very High Very High Very High
COX2 15 99.72 Very High Very High Very High
Inflammation 723 99.60 Very High Very High Very High
Osteoarthritis 180 99.22 Very High Very High Very High
dexamethasone 10 99.12 Very High Very High Very High
antagonist 31 98.96 Very High Very High Very High
substance P 21 98.62 Very High Very High Very High
corticosteroid 2 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rickets 2 99.92 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.84 Very High Very High Very High
Osteoporosis 22 99.84 Very High Very High Very High
Cancer 228 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 99.70 Very High Very High Very High
INFLAMMATION 832 99.60 Very High Very High Very High
Necrosis 40 99.52 Very High Very High Very High
Osteoarthritis 138 99.22 Very High Very High Very High
Carcinoma 17 99.22 Very High Very High Very High
Choroideremia 166 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local episodic synthesis and secretion of sub-nanogram concentrates of the cytokine is considered to play a significant role in the pathogenesis of osteoarthritis (OA) by preventing matrix repair. (2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.
Gene_expression (synthesis) of IL1 associated with osteoarthritis and cytokine
1) Confidence 0.78 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.50 Pain Relevance 0.34
It is suggested that these NSAIDs induce IL1 synthesis by diminishing PG levels.
Gene_expression (synthesis) of IL1 associated with cinod
2) Confidence 0.78 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.59 Pain Relevance 0.64
It is suggested that this action is due to the suppression of a positive feedback loop for local IL1 synthesis and secretion. (3) Certain non-steroidal anti-inflammatory drugs (NSAIDs), in particular Indomethacin, Ibuprofen and Naproxen, cause inhibition of GAG synthesis, and hence may diminish the potentiality for repair in arthritic cartilage.
Gene_expression (synthesis) of IL1 in cartilage associated with inflammation, cinod and arthritis
3) Confidence 0.78 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.51 Pain Relevance 0.50
It is suggested that the stimulatory action of group 1 NSAID is due to inhibition of locally produced IL1 and consequent expression of growth factor activity.
Gene_expression (expression) of IL1 associated with cinod
4) Confidence 0.77 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.61 Pain Relevance 0.81
Other NSAIDs may also inhibit IL1 synthesis or release, but probably do not have a beneficial effect on chondrocyte synthetic activity as they have toxic effects on cartilage metabolism.
Gene_expression (synthesis) of IL1 in chondrocyte associated with cinod
5) Confidence 0.77 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.39 Pain Relevance 0.69
It is suggested that the stimulatory action of group 1 NSAID is due to inhibition of locally produced IL1 and consequent expression of growth factor activity.
Gene_expression (produced) of IL1 associated with cinod
6) Confidence 0.77 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.61 Pain Relevance 0.81
IL-1alpha and IL-1beta were not expressed at significantly higher levels in symptomatic versus clinically healthy pulps, while the difference was significant for the other cytokines (log-rank test, P<0.05).
Neg (not) Gene_expression (expressed) of IL-1alpha associated with cytokine
7) Confidence 0.75 Published 2003 Journal Cytokine Section Abstract Doc Link 12849707 Disease Relevance 0.25 Pain Relevance 0.45
SP (10(-5) M) also induced a significant but transient increase in the production of IL-1alpha, IL-1beta, IL-1 receptor antagonist and IL-8 which was detectable by ELISA techniques 6 h after stimulation.
Gene_expression (production) of IL-1alpha associated with antagonist and substance p
8) Confidence 0.75 Published 1996 Journal Arch. Dermatol. Res. Section Abstract Doc Link 8932586 Disease Relevance 0 Pain Relevance 0.61
Flufenamic acid and 15-deoxy-Delta(12,14)-prostaglandin J(2) also inhibit LPS-induced expression of inducible form of nitric-oxide synthase and interleukin-1alpha in RAW 264.7 cells.
Gene_expression (expression) of interleukin-1alpha in RAW 264
9) Confidence 0.75 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10866999 Disease Relevance 0.42 Pain Relevance 0.61
Monocytes/macrophages must be considered an important reservoir of HIV in vivo and a producer of cytokines such as Interleukin-1 (IL1) and tumor necrosis factor (TNF).
Gene_expression (producer) of IL1 in reservoir associated with necrosis, cancer, acquired immune deficiency syndrome or hiv infection and cytokine
10) Confidence 0.73 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 1.03 Pain Relevance 0.20
In particular, their use is considered for their ability to decrease IL1 and TNF production by monocytes/macrophages, as demonstrated by many authors.
Gene_expression (production) of IL1 in macrophages
11) Confidence 0.73 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 0.97 Pain Relevance 0.24
Monocytes/macrophages must be considered an important reservoir of HIV in vivo and a producer of cytokines such as Interleukin-1 (IL1) and tumor necrosis factor (TNF).
Gene_expression (producer) of Interleukin-1 in reservoir associated with necrosis, cancer, acquired immune deficiency syndrome or hiv infection and cytokine
12) Confidence 0.73 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 1.03 Pain Relevance 0.20
In IL1-A, polymorphism C/T in region -889 of the promoter was studied; the T allele causes higher IL1-A expression[31].
Gene_expression (expression) of IL1
13) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2626602 Disease Relevance 0 Pain Relevance 0
Interleukin-1 alpha (IL-1 alpha) is myeloprotective in a variety of animal models of cancer chemotherapy and is similarly beneficial in adults treated with carboplatin, 5-fluorouracil, and after autologous bone marrow transplantation.
Gene_expression (myeloprotective) of Interleukin-1 alpha in bone marrow associated with cancer
14) Confidence 0.68 Published 1997 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 9143391 Disease Relevance 0.46 Pain Relevance 0
Intravenous injection of recombinant human interleukin-1 alpha (r.
Gene_expression (injection) of HuIL-1 alpha
15) Confidence 0.67 Published 1994 Journal Vet Q Section Abstract Doc Link 8009810 Disease Relevance 0.63 Pain Relevance 0.08
In addition, a minor haplotype, with a frequency of 7.5% in the study population, including the minor alleles of IL1A c.1-889C>T, IL1RN c.1812G>A, and IL1RN c.1506G>A, was significantly associated with Modic changes.
Gene_expression (c.1812G>A) of IL1A
16) Confidence 0.65 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19701653 Disease Relevance 0.05 Pain Relevance 0.09
The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth.
Neg (not) Gene_expression (levels) of IL-1alpha associated with cancer, acular and carcinoma
17) Confidence 0.65 Published 2000 Journal FASEB J. Section Abstract Doc Link 10928984 Disease Relevance 1.05 Pain Relevance 0.35
precursor resulting in an increase in the levels of active IL1-?
Gene_expression (levels) of IL1
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.79 Pain Relevance 0.18
IL1A:rs17561 is a non-synonymous SNP and increases processing of the IL1-?
Gene_expression (processing) of IL1
19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.74 Pain Relevance 0.18
It was a remarkable and encouraging observation that the course of ILI monitored by GIS so closely resembled the official survey of ILI by GPs participating in EISS.
Gene_expression (participating) of ILI
20) Confidence 0.65 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1609118 Disease Relevance 0.09 Pain Relevance 0

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