INT164451

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.38
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Zmat3)
Anatomy Link Frequency
plasma 2
liver 2
Zmat3 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 28 100.00 Very High Very High Very High
hyperpathia 1 85.80 High High
cytokine 26 77.20 Quite High
chemokine 50 76.48 Quite High
agonist 8 10.08 Low Low
Substantia nigra 40 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 28 100.00 Very High Very High Very High
Urological Neuroanatomy 22 99.98 Very High Very High Very High
Disease 66 98.96 Very High Very High Very High
Pressure And Volume Under Development 11 98.04 Very High Very High Very High
Targeted Disruption 70 95.84 Very High Very High Very High
Reperfusion Injury 14 95.16 Very High Very High Very High
Injury 112 94.44 High High
Diabetic Nephropathy 1 92.60 High High
Hyperalgesia 1 85.80 High High
Neuropathic Pain 1 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of wild-type SPT1 subunit
1) Confidence 0.02 Published 2009 Journal J. Neurosci. Section Title Doc Link 19923297 Disease Relevance 0.46 Pain Relevance 0.09
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Positive_regulation (increased) of Gene_expression (expression) of wild-type associated with disease
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.52 Pain Relevance 0
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of wild-type associated with disease
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.58 Pain Relevance 0
The liver MPO levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated compared to the sham-operated mice at the corresponding time points.
Positive_regulation (elevated) of Gene_expression (levels) of wild-type in liver associated with ischemia and urological neuroanatomy
4) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 1.03 Pain Relevance 0.30
The plasma ALT levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated when compared to their respective sham-operated mice (Figure 2).
Positive_regulation (elevated) of Gene_expression (levels) of wild-type in plasma associated with ischemia
5) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.38 Pain Relevance 0.05
Bmal1 expression level was higher in the mutant mice than that of wild-type [39].
Positive_regulation (higher) of Gene_expression (expression) of wild-type
6) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.17 Pain Relevance 0
The loss of these currents could be rescued by overexpression of wild-type dBest1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of wild-type
7) Confidence 0.01 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.23 Pain Relevance 0

General Comments

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