INT164452

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Sptlc1) biosynthetic process (Sptlc1) transferase activity, transferring acyl groups (Sptlc1)
Sptlc1 (Mus musculus)
Sptlc1 - C133W (1)
Pain Link Frequency Relevance Heat
hyperpathia 3 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.88 Very High Very High Very High
Hyperalgesia 3 98.16 Very High Very High Very High
Diabetic Nephropathy 3 97.20 Very High Very High Very High
Neuropathic Pain 3 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that mice bearing a transgene-expressing mutant SPTLC1 (tgSPTLC1(C133W)) show a reduction in SPT activity and hyperpathia at 10 months of age.
Gene_expression (expressing) of tgSPTLC1 (C133W) associated with hyperpathia
1) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.42 Pain Relevance 0.10
We previously reported that mice bearing a transgene-expressing mutant SPTLC1 (tgSPTLC1(C133W)) show a reduction in SPT activity and hyperpathia at 10 months of age.
Gene_expression (expressing) of SPTLC1 associated with hyperpathia
2) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.42 Pain Relevance 0.10
This phenotype is largely reversed when these mice are crossed with transgenic mice overexpressing wild-type SPTLC1 showing that the mutant SPTLC1 protein is not inherently toxic.
Gene_expression (overexpressing) of SPTLC1 associated with targeted disruption
3) Confidence 0.51 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.53 Pain Relevance 0.09

General Comments

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