INT164465

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 10.31
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sbp) molecular_function (Sbp) biological_process (Sbp)
Anatomy Link Frequency
blood 3
kidney 1
Sbp (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 14 99.14 Very High Very High Very High
cva 14 74.56 Quite High
beta blocker 53 74.52 Quite High
ischemia 7 71.44 Quite High
withdrawal 3 64.32 Quite High
nud 6 63.84 Quite High
headache 13 63.40 Quite High
Analgesic 3 57.28 Quite High
Calcium channel 47 52.40 Quite High
anesthesia 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 54 99.84 Very High Very High Very High
Cv Unclassified Under Development 13 98.96 Very High Very High Very High
Dizziness 14 98.28 Very High Very High Very High
Sprains And Strains 492 98.12 Very High Very High Very High
Weight Loss 21 98.02 Very High Very High Very High
Retina Disease 14 96.64 Very High Very High Very High
Myocardial Infarction 67 96.04 Very High Very High Very High
Heart Rate Under Development 130 95.96 Very High Very High Very High
Cognitive Disorder 14 95.88 Very High Very High Very High
Chronic Renal Failure 49 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 24-hour ambulatory mean SBP and DBP also decreased significantly in both IIT and PP analyses {ITT (ABPM SBP), from 140.4±13.5 to 133.8±11.6 mmHg, p<0.0001; ITT (ABPM DBP), from 91.7±8.7 to 87.5±9.5 mmHg, p<0.0001; PP (ABPM SBP), from 139.6±11.9 to 133.5±11.7 mmHg, p<0.0001; PP (ABPM DBP), from 91.5±8.8 to 87.5±9.6 mmHg, p<0.0001}.


Negative_regulation (decreased) of SBP
1) Confidence 0.33 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978294 Disease Relevance 0.24 Pain Relevance 0.10
The trough SiSBP and SiDBP decreased significantly from baseline to week 12 in both ITT and PP analyses {ITT (SiSBP), from 144.6± to 132.9± mmHg, p<0.0001; ITT (SiDBP), from 96.9± to 88.3± mmHg, p<0.0001; PP (SiSBP), from 144.2± to 131.3± mmHg, p<0.0001; PP (SiDBP), from 96.7± to 87.7± mmHg, p<0.0001}.
Spec (analyses) Negative_regulation (decreased) of SiSBP
2) Confidence 0.33 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978294 Disease Relevance 0.35 Pain Relevance 0.13
The trough BP {sitting systolic blood pressure (SiSBP) and SiDBP} and 24-hour mean BP also decreased significantly (SiSBP: from 144.6±8.2 to 132.9±13.5 mmHg, p<0.0001; SiDBP: from 96.9±5.4 to 88.3±8.6 mmHg, p<0.0001, 24-hour mean systolic BP: from 140.4±13.5 to 133.8±11.6 mmHg, p<0.0001; 24-hour mean diastolic BP: from 91.7±8.7 to 87.5±9.5 mmHg, p<0.0001).


Negative_regulation (decreased) of SiSBP in blood
3) Confidence 0.33 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978294 Disease Relevance 0.13 Pain Relevance 0.03
The three strains standing between these two groups correlate with very mild variations of VW, HW, and VWI under both concentrations of iso as well as decreased SBP under iso1.
Negative_regulation (decreased) of SBP associated with sprains and strains
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.58 Pain Relevance 0
Ate tended to slightly decrease SBP, but the effect was below significance in all strains except C57BL/6J (Figure 4).
Negative_regulation (decrease) of SBP associated with sprains and strains
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.62 Pain Relevance 0
Even though conservation across independent datasets was much reduced for SBP and HR, the number of significant between-projects correlations was higher than expected by chance for both traits.
Negative_regulation (reduced) of SBP
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.35 Pain Relevance 0.06
Determining the presence of postural hypotension, ie, a decrease of at least 20 mmHg in the SBP or 10 mmHg in the DBP in association with reported symptoms of dizziness or light-headedness within the first 2–5 minutes of assuming an upright posture, is also necessary in order to avoid increasing the risk of falls with the addition of antihypertensive medications.
Negative_regulation (decrease) of SBP associated with pressure volume 2 under development and dizziness
7) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 0.72 Pain Relevance 0
Weight reduction, aerobic exercise, and a decrease in sodium and alcohol intake can each result in up to a 10 mmHg decrease in SBP which is equivalent to that achieved with monotherapy.
Negative_regulation (decrease) of SBP associated with weight loss and alcohol
8) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.16 Pain Relevance 0.12
Secondly, patients who fail to decrease their average nocturnal SBP by at least 10% of the average daytime SBP value (non-dippers) have been found to possess a more adverse cardiovascular risk profile compared with those who do drop by >10% (dippers).14
Neg (fail) Negative_regulation (decrease) of SBP
9) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.00 Pain Relevance 0
It has been shown that a 10 mmHg reduction in systolic blood pressure (SBP) and a 5 mmHg reduction in diastolic blood pressure (DBP) significantly decrease the incidence of myocardial infarction, stroke, CHF, and overall mortality.
Negative_regulation (reduction) of SBP in blood associated with heart rate under development, stroke and myocardial infarction
10) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.76 Pain Relevance 0
For example, if a patient’s seated SBP cannot be lowered to <140 mmHg without inducing significant orthostasis, then a focus on standing SBP may be a more prudent approach.
Negative_regulation (lowered) of SBP associated with dizziness
11) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.16 Pain Relevance 0
Active treatment consisted of nitrendipine 10–40 mg/day with the possible addition of enalapril 5–20 mg/day and/or hydrochlorothiazide 12.5–25 mg/day, and this regimen achieved a 23/7 mmHg reduction in SBP and DBP, respectively, compared with 13/2 mmHg in the placebo group.17 Overall, significant reductions in mortality (12%–25%), stroke (35%), and myocardial infarction (25%), as well as chronic kidney disease (CKD) and CHF, have been demonstrated with active therapy.
Negative_regulation (reduction) of SBP in kidney associated with heart rate under development, chronic renal failure, stroke and myocardial infarction
12) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.11 Pain Relevance 0.09
Put in terms of the number needed to treat (assuming a decrease in SBP of 12 mmHg over 10 years), anywhere from 9 (highest-risk group) to 81 (lowest-risk group) patients would need to be treated to prevent one death.
Negative_regulation (decrease) of SBP associated with death
13) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.07 Pain Relevance 0.03
The incidence of hypotension (defined as a 20% reduction in SBP from the baseline), ephedrine use, and umbilical cord blood gases were also compared.
Negative_regulation (reduction) of SBP in blood
14) Confidence 0.03 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19923521 Disease Relevance 0.07 Pain Relevance 0

General Comments

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