INT16447

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.01
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
EL4 1
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 234 99.84 Very High Very High Very High
Inflammation 43 98.88 Very High Very High Very High
antagonist 8 98.12 Very High Very High Very High
cINOD 1 96.88 Very High Very High Very High
adenocard 12 96.24 Very High Very High Very High
spinal inflammation 4 95.20 Very High Very High Very High
dexamethasone 2 93.52 High High
chemokine 17 88.52 High High
Chronic pancreatitis 1 88.40 High High
Osteoarthritis 112 85.96 High High
Disease Link Frequency Relevance Heat
Thymoma 2 98.92 Very High Very High Very High
INFLAMMATION 49 98.88 Very High Very High Very High
Fibrosis 3 95.36 Very High Very High Very High
Low Back Pain 5 95.20 Very High Very High Very High
Sleep Disorders 20 93.36 High High
Immunization 4 91.04 High High
Increased Venous Pressure Under Development 11 90.64 High High
Disorder Of Lipid Metabolism 1 86.56 High High
Osteoarthritis 114 85.96 High High
Hypoxia 11 80.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some sera with IL-1 alpha BF and purified IgG thereof were able to inhibit by 96% to 98% the binding of human recombinant IL-1 alpha to its receptor on murine thymoma EL4-6.1 cells, whereas other sera did not.
IL-1 alpha Binding (binding) of in EL4 associated with thymoma
1) Confidence 0.45 Published 1991 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1831824 Disease Relevance 0.41 Pain Relevance 0.08
OBJECTIVE: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP).
IL1 Binding (binds) of associated with cytokine
2) Confidence 0.36 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.10 Pain Relevance 0.18
IL-18 is a proinflammatory cytokine of the IL-1 family, recognized for its ability to promote IFN-gamma secretion.
IL-1 Binding (recognized) of associated with cytokine
3) Confidence 0.36 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 0.85 Pain Relevance 0.57
Using gene names also for their protein products, a complex of IL-1 (IL1A or IL1B), IL1RI and IL1RAP are needed for signal transduction.
IL1A Binding (complex) of
4) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.69 Pain Relevance 0.43
IL-1 receptor antagonist (IL-1Ra) is a protein that binds to IL-1 receptors and competitively inhibits the binding of IL-1alpha and IL-1beta.
IL-1alpha Binding (binding) of associated with antagonist
5) Confidence 0.35 Published 2005 Journal J. Rheumatol. Section Abstract Doc Link 16206345 Disease Relevance 0.59 Pain Relevance 0.47
IL-1 alpha binding activity resided in the F(ab)2 fragment.
IL-1 alpha Binding (binding) of
6) Confidence 0.33 Published 1991 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1831824 Disease Relevance 0.38 Pain Relevance 0.04
TNF alpha (and interleukin-1 alpha) also countered the effects of TGF-beta and bFGF.
interleukin-1 alpha Binding (countered) of
7) Confidence 0.14 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.41 Pain Relevance 0.41
The system recognizes macaque IL1?
IL1 Binding (recognizes) of
8) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0 Pain Relevance 0.09
, IL1, and IL6, they can be interpreted collectively as markers of inflammation.
IL1 Binding (interpreted) of associated with inflammation
9) Confidence 0.13 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.27 Pain Relevance 0.42
B protein by IL1 and TNF-?
IL1 Binding (by) of
10) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.32 Pain Relevance 0.09

General Comments

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