INT164489

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
spinal cord 2
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.82 Very High Very High Very High
Hyperalgesia 1 96.08 Very High Very High Very High
Sciatic nerve 2 88.32 High High
Eae 1 75.12 Quite High
Neuropathic pain 2 75.00 Quite High
Kinase C 2 75.00 Quite High
Pain 5 67.60 Quite High
agonist 23 62.80 Quite High
Antihyperalgesic 1 61.28 Quite High
cINOD 3 33.52 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 1 96.08 Very High Very High Very High
Injury 3 86.88 High High
Neuropathic Pain 3 75.00 Quite High
Pain 2 67.60 Quite High
Toxicity 5 54.84 Quite High
INFLAMMATION 5 33.12 Quite Low
Death 13 25.80 Quite Low
Apoptosis 8 19.28 Low Low
Atherosclerosis 11 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Regulation (detected) of Gene_expression (levels) of JNK in spinal cord associated with spinal cord
1) Confidence 0.44 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.71
The levels of JNK (JNK 1 and JNK 2), however, were not altered (Fig. 5).
Neg (not) Regulation (altered) of Gene_expression (levels) of JNK
2) Confidence 0.03 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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