INT16449

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 67
Total Number 72
Disease Relevance 39.55
Pain Relevance 10.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma 2
plasma cells 2
cerebrospinal fluid 2
14.1 1
M-1 1
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 175 100.00 Very High Very High Very High
Morphine 59 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Inflammation 199 99.98 Very High Very High Very High
Central nervous system 27 99.84 Very High Very High Very High
addiction 6 99.32 Very High Very High Very High
Analgesic 6 98.12 Very High Very High Very High
fibrosis 295 98.08 Very High Very High Very High
imagery 53 98.04 Very High Very High Very High
intrathecal 2 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 366 100.00 Very High Very High Very High
Rheumatoid Arthritis 188 100.00 Very High Very High Very High
INFLAMMATION 212 99.98 Very High Very High Very High
Meningitis 14 99.98 Very High Very High Very High
Disease 530 99.96 Very High Very High Very High
Central Nervous System Disease 11 99.84 Very High Very High Very High
Neuropathy 58 99.80 Very High Very High Very High
Rhinitis 81 99.76 Very High Very High Very High
Pemphigoid 45 99.72 Very High Very High Very High
Injury 18 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly however, any overlap between NRF and CRF could be excluded based on the following arguments: (a) Western blotting shows no IgG4 Fab- Ig Fc (CRF) interaction and (b) ELISA showed that serum level of IgG4 bound to each IgG subclass correlated well with the serum IgG4 level itself (i.e. the totality of IgG4-Ig interaction is through Fc-Fc engagement), and (c) the reciprocal absence of any link between IgG-bound IgG4 levels and RF, excluding therefore any CRF reactivity (Figure 5).
IgG4-Ig Binding (interaction) of
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.16 Pain Relevance 0.08
It is equally noteworthy that this IgG4 Fc–Ig Fc interaction extends beyond man to a number of other animal IgG.
IgG4 Binding (interaction) of
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.27 Pain Relevance 0.07
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
IgG Binding (interaction) of
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.81 Pain Relevance 0.20
Is it limited to IgG4 or could be found for other IgG subclasses or Ig classes?
IgG4 Binding (limited) of
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.32 Pain Relevance 0.03
It is equally noteworthy that this IgG4 Fc–Ig Fc interaction extends beyond man to a number of other animal IgG.
IgG Binding (extends) of
5) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.28 Pain Relevance 0.07
The capacity of IgG4 to act as RF was assessed by examining its binding capacity for human IgG1 or IgG2 or IgG3 in ELISA.
IgG3 Spec (examining) Binding (capacity) of
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.05 Pain Relevance 0
Importantly however, any overlap between NRF and CRF could be excluded based on the following arguments: (a) Western blotting shows no IgG4 Fab- Ig Fc (CRF) interaction and (b) ELISA showed that serum level of IgG4 bound to each IgG subclass correlated well with the serum IgG4 level itself (i.e. the totality of IgG4-Ig interaction is through Fc-Fc engagement), and (c) the reciprocal absence of any link between IgG-bound IgG4 levels and RF, excluding therefore any CRF reactivity (Figure 5).
IgG4 Binding (bound) of
7) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.20 Pain Relevance 0.08
In more general terms and despite the fact that is is likely premature to speculate much on the physiological/pathological effects of IgG4 Fc-IgG Fc complexes in vivo, several not exclusive situations could be envisioned based on circumstantial evidences. (1) IgG4 Fc-Fc binding may have a pathological role within the inflammatory process, or even induce inflammation per se.
IgG4 Binding (binding) of associated with inflammation
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.92 Pain Relevance 0.10
Western blot analysis showed that IgG4 did indeed bind to IgG1?
IgG4 Binding (bind) of
9) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.38 Pain Relevance 0
IgG4 Fc-Fc binding may therefore indeed induce aggregation of immunoglobulins.
IgG4 Binding (binding) of
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.66 Pain Relevance 0.09
IgG4, quantitatively the least prevalent of all human IgG subclasses, has two unique features: not being able to activate the classical complement pathway and to bind antigen with low affinity [22].
IgG4 Binding (bind) of
11) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 1.65 Pain Relevance 0.11
In conclusion, a sequential set of experiments, aimed initially to confirm the mode of interaction of supposedly RF-like autoantibodies to their cognate autoantigens revealed the unexpected fact that IgG4 autoantibodies interact in vivo with IgG autoantigen in an unprecedented topology.
IgG4 Binding (interact) of
12) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.14 Pain Relevance 0.07
Factor-2 scores showed no significant association with IgG anti-P. falciparum or with pre-exposure to Plasmodium species.
IgG Neg (no) Binding (association) of
13) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.19 Pain Relevance 0
In contrast, factor-2 scores were positively influenced mainly by IgG reactivity, while a number of IgM bands had a negative impact.
IgG Binding (reactivity) of in bands
14) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.29 Pain Relevance 0
Factor-2 represented a relative dominance of IgG reactivity against some IgM.
IgG Binding (reactivity) of
15) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.27 Pain Relevance 0
In the adult group, the association of the IgG3 anti-MSP3 responses with protection was significant for the year following sampling (OR 14.1, p = 0.019) but no longer significant, in the ensuing years (as shown in Table S2).
IgG3 Binding (association) of in 14.1
16) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0 Pain Relevance 0
In contrast, in the children group, a significant association of IgG3 anti-MSP-3 antibodies with clinical protection was observed in the following 12, 24, and 36 mo of follow-up (respective ORs 56.1, p = 0.0063; 34.8, p = 0.01, and 31.7, p = 0.009).
IgG3 Binding (association) of
17) Confidence 0.29 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0 Pain Relevance 0
Among the 121 individuals of the “adults” group, analyses of data by ordinal logistic regression showed that only MSP3 IgG3 and the C:NC ratio of MSP3 were associated with protection, i.e., negatively correlated with the number of malaria attacks (L-R Chi-square = 6.91; p = 0.0086 and L-R Chi-square = 10.84; p = 0.001 respectively).
MSP3 IgG3 Binding (associated) of associated with malaria
18) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.17 Pain Relevance 0
Dependence of chemiluminescence activity on IgG and complement
IgG Binding (complement) of associated with addiction
19) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.05
Bound secondary antibodies for IgG and IgM, and a third antibody group for IgG subclasses were quantified using ready-to-use TMB (3,3?
IgG Binding (group) of
20) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0 Pain Relevance 0

General Comments

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