INT1645

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Context Info
Confidence 0.42
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 1.71
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
muscle 6
blood 2
liver 1
follicle 1
median nerve 1
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 8 99.80 Very High Very High Very High
imagery 125 99.72 Very High Very High Very High
Clonidine 6 99.24 Very High Very High Very High
Morphine 20 99.00 Very High Very High Very High
antagonist 10 95.20 Very High Very High Very High
Dopamine 12 91.20 High High
carbamazepine 5 88.88 High High
anticonvulsant 2 88.28 High High
opiate 1 83.68 Quite High
corticosteroid 81 77.28 Quite High
Disease Link Frequency Relevance Heat
Frailty 190 99.90 Very High Very High Very High
Rheumatoid Arthritis 31 98.36 Very High Very High Very High
Death 21 96.08 Very High Very High Very High
Stroke 8 92.60 High High
Handedness 1 91.00 High High
Aging 66 82.80 Quite High
Injury 50 81.76 Quite High
Organ Transplantation 12 72.04 Quite High
Mobility Limitation 25 69.60 Quite High
Obesity 42 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, a Lineweaver-Burk analysis of the erythromycin-mediated inhibition of CsA oxidase activity in human liver microsomes revealed competitive inhibition (with Ki of 75 microM) as expected, this macrolide being a specific substrate of P-450IIIA.
Negative_regulation (inhibition) of CsA in liver
1) Confidence 0.42 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0
Using this experimental approach, 59 molecules representative of 17 different therapeutic classes were screened for inducers and inhibitors of CsA oxidase activity.
Negative_regulation (inhibitors) of CsA
2) Confidence 0.31 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0.10
Conversely, these cultures exhibited erythromycin concentration-dependent decreases in CsA oxidase activity when incubated in the presence of 5, 20, and 100 microM erythromycin.
Negative_regulation (decreases) of CsA
3) Confidence 0.31 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0
Magnetic resonance imaging (MRI) was used to determine the muscle CSA and muscle volume of the left and right RA.
Spec (determine) Negative_regulation (determine) of CSA in muscle associated with rheumatoid arthritis and imagery
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013134 Disease Relevance 0.47 Pain Relevance 0.23
The human placental lactogen-induced decrease in regional blood flow was not affected by blockade of cholinergic receptors (5 pigs) or of alpha-adrenergic receptors (5 pigs), but it was abolished by blockade of beta2-adrenergic receptors (5 pigs).
Negative_regulation (decrease) of placental lactogen in blood
5) Confidence 0.21 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16410683 Disease Relevance 0 Pain Relevance 0
The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels.
Negative_regulation (reduce) of PL in follicle associated with narcan and clonidine
6) Confidence 0.18 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.94
The presurgical value of CSA-I is a predictor of postsurgical normalization of clinical parameters and of its own value.


Negative_regulation (value) of CSA-I
7) Confidence 0.14 Published 2008 Journal Scand. J. Rheumatol. Section Body Doc Link 18465458 Disease Relevance 0 Pain Relevance 0
Therefore, in the absence of sVEGFR1 expression, the control VEGF-secretion rates necessary to achieve the targeted [V]pl of 1.5 pM, as well as symmetric [V]IS (i.e., 15 pM in both “calf” and “normal” interstitia), would have been qV,-Ctrl?
Negative_regulation (achieve) of pl
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Men and women showed significant and nearly identical decreases in total muscle CSA after 14 D of immobilization (men?
Negative_regulation (decreases) of CSA in muscle
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
Reduced thigh CSA was associated with poorer LEP, as was reduced thigh muscle attenuation coefficient, even after the adjustment for muscle area.
Negative_regulation (Reduced) of CSA in muscle
10) Confidence 0.09 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0
In addition to the loss of fast motor units, there appears to be fiber atrophy, or loss of CSA, of type II fast glycolytic fibers [13, 14].
Negative_regulation (loss) of CSA associated with frailty
11) Confidence 0.09 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.33 Pain Relevance 0
All patients received maintenance CSA and steroid therapy.
Negative_regulation (received) of CSA
12) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.10 Pain Relevance 0.04
Studies which assess muscle mass through CSA measurement have found that CSA decreases by roughly 40% between 20 and 60 years, with the reported amount varying with imaging technique, skeletal site, and gender [9, 16].
Negative_regulation (decreases) of CSA in muscle associated with imagery
13) Confidence 0.07 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0 Pain Relevance 0.18
Reduced thigh CSA was associated with poorer LEP, as was reduced thigh muscle attenuation coefficient, even after the adjustment for muscle area.
Negative_regulation (reduced) of CSA in muscle
14) Confidence 0.07 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.32 Pain Relevance 0
As a result, although there is relatively little change in the average CSA of type I fibers, the percentage of the total muscle cross-sectional area occupied by type I fibers tends to increase with age, whereas not only are type II fibers lost but the CSA and the aggregate power-generating capacity of the remaining fibers also decrease dramatically.
Negative_regulation (decrease) of CSA in muscle
15) Confidence 0.07 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.18 Pain Relevance 0
Csa and tacrolimus are calcineurin inhibitors that bind to their specific immunophilins, cyclophilin and FK binding protein, respectively, before the drug-receptor complex binds to and inhibits calcineurin, a calcium-dependent phosphatase.
Negative_regulation (inhibitors) of Csa
16) Confidence 0.06 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.07 Pain Relevance 0
This interaction has been reported to produce a marked reduction in the blood concentrations of Csa, resulting in subtherapeutic levels, rejection of transplanted organs, and graft loss.
Negative_regulation (reduction) of Csa in blood
17) Confidence 0.06 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0 Pain Relevance 0.12
We observed a difference between the CSA and ADC, but not the FA, of the median nerve at the distal forearm and proximal carpal tunnel levels.


Negative_regulation (difference) of CSA in median nerve
18) Confidence 0.03 Published 2009 Journal Skeletal Radiol. Section Body Doc Link 19132371 Disease Relevance 0 Pain Relevance 0
Therefore SCH 39166 impaired morphine-CSA when given shortly before the drug, while it impaired LiCl-CSA when given shortly after saccharin.
Negative_regulation (impaired) of LiCl-CSA associated with morphine
19) Confidence 0.02 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 18790704 Disease Relevance 0 Pain Relevance 1.09
In contrast SCH 39166 reduced LiCl-CSA when administered 45' before the drug and even more so when administered 105' before LiCl i.e. immediately after saccharin drinking.
Negative_regulation (reduced) of LiCl-CSA
20) Confidence 0.02 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 18790704 Disease Relevance 0 Pain Relevance 1.01

General Comments

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