INT16450

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
neurons 10
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 1 99.82 Very High Very High Very High
midbrain 8 99.76 Very High Very High Very High
Dopamine 330 96.04 Very High Very High Very High
Enkephalin 10 95.32 Very High Very High Very High
agonist 33 94.24 High High
Ventral tegmentum 7 93.80 High High
antagonist 42 93.72 High High
cocaine 6 92.88 High High
Substantia nigra 10 92.72 High High
Eae 3 92.00 High High
Disease Link Frequency Relevance Heat
Movement Disorders 2 15.12 Low Low
Disease 22 5.00 Very Low Very Low Very Low
Parkinson's Disease 21 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
Neg (not) Positive_regulation (result) of Positive_regulation (increase) of D2 mRNA in neurons associated with midbrain
1) Confidence 0.41 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.37
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
Positive_regulation (increase) of Positive_regulation (half-life) of D2 in neurons associated with midbrain
2) Confidence 0.41 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.37
Since D2 receptor mRNA is generally colocalized with proenkephalin mRNA in striatal neurons, these results demonstrate what is likely a selective cellular increase in proenkephalin mRNA without a parallel increase in D2 mRNA.
Positive_regulation (increase) of Neg (without) Positive_regulation (increase) of D2 mRNA in neurons
3) Confidence 0.41 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.26
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
Neg (not) Positive_regulation (result) of Positive_regulation (half-life) of D2 in neurons associated with midbrain
4) Confidence 0.41 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.37
It is concluded that the opioid agonists studied induce a significant elevation in functional D2 sites to the exclusion of D1 sites.
Positive_regulation (induce) of Positive_regulation (elevation) of D2 associated with mu agonist
5) Confidence 0.37 Published 1991 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1831883 Disease Relevance 0 Pain Relevance 0.86
These data indicate that this administration paradigm elevates both preprodynorphin and preproenkephalin mRNAs by a D1-dependent mechanism not requiring D2 activation.
Neg (not) Positive_regulation (requiring) of Neg (not) Positive_regulation (activation) of D2
6) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930988 Disease Relevance 0 Pain Relevance 0.79
We have recently carried out preliminary studies indicating that activation of D1LRs or D2LRs in the monkey STN increases the firing rates of STN neurons, and that D1LR activation decreases bursting activities of these neurons (Rommelfanger et al., 2010).
Positive_regulation (increases) of Positive_regulation (activation) of D2LRs in neurons
7) Confidence 0.14 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.47
suppression of EPSPs is largely dependent upon activation of D2-like
Positive_regulation (dependent) of Positive_regulation (activation) of D2
8) Confidence 0.10 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.42
suppression of EPSPs is largely dependent upon activation of D2-like
Positive_regulation (upon) of Positive_regulation (activation) of D2
9) Confidence 0.10 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.42

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