INT164512

Context Info Confidence 0.30 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 13 Disease Relevance 8.38 Pain Relevance 1.53

structural molecule activity (MPZ) plasma membrane (MPZ)

Anatomy Link Frequency autonomic nervous system 1 body 1 MPZ (Homo sapiens)

Pain Link Frequency Relevance Heat Pain score 16 98.52 Pain 174 97.96 nociceptor 16 94.00 vincristine 1 92.32 Inflammation 185 90.92 Catecholamine 1 88.80 imagery 1 87.92 Dysuria 1 51.96 rheumatoid arthritis 27 51.56 Inflammatory mediators 8 27.28

Disease Link Frequency Relevance Heat Dengue Hemorrhagic Fever 477 100.00 Dengue 239 100.00 Ganglion Cysts 1 99.68 Neuropathy 67 99.46 Metatarsalgia 216 98.28 Pain 184 98.24 Autonomic Nervous System Disease 3 97.78 Cancer 2 97.04 Disorder Of Lipid Metabolism 4 97.00 Obesity 32 96.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We provide a global while non exhaustive overview of the molecular mechanisms altered in of DSS children and suggest how they may interact to lead to final vascular homeostasis breakdown.

Regulation (altered) of DSS associated with dengue hemorrhagic fever

1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2907396 Disease Relevance 1.38 Pain Relevance 0.17

Finally, the absolute values of the MPP and PTI are not correlated to the treatment results.

Regulation (values) of MPP

2) Confidence 0.26 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.41 Pain Relevance 0.07

For axonal neuropathy, DNA sequencing tests are available for Cx32, MPZ, NF-L and MNF2.

Regulation (available) of MPZ associated with neuropathy

3) Confidence 0.25 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2771953 Disease Relevance 1.04 Pain Relevance 0.07

Selectively distributed dysautonomia in this pedigree may indicate parasympathetic postganglionic components including the ganglion as the primary target of this mutated MPZ in the autonomic nervous system.

Regulation (target) of MPZ in autonomic nervous system associated with ganglion cysts and autonomic nervous system disease

4) Confidence 0.23 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19928689 Disease Relevance 0.84 Pain Relevance 0.14

The pre- and post-treatment MPP and PTI values or the DS in the MPP position in the matrix were not statistically correlated to changes in the VAS (Table 4).

Regulation (values) of MPP

5) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0 Pain Relevance 0

However, neither the pre-treatment values of the MPP and PTI shift in the position of the MPP after treatment, nor the age, gender and body mass index (BMI) of the subjects were statistically correlated with subjective improvement.

Regulation (values) of MPP in body associated with obesity

6) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.67 Pain Relevance 0.22

Declines in the PTI and MPP values after MP application were statistically correlated with the improvement in VAS scores (r = 0.77, R2 = 0.59, p < 0.001; r = 0.60, R2 = 0.36, p = 0.009).

Regulation (values) of MPP

7) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.49 Pain Relevance 0.15

We found that the decline in the PTI and MPP values after MP application was correlated to subjective pain improvement.

Regulation (values) of MPP associated with pain

8) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.47 Pain Relevance 0.10

Readjustment of MP placements for those who failed to demonstrate a decline in the PTI and MPP values after treatment should be considered to improve treatment results.

Regulation (values) of MPP

9) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.39 Pain Relevance 0

Declines in the PTI and MPP values after MP placement significantly correlated to the decrease in the VAS scores (r = 0.77, R2 = 0.59, p < 0.001; r = 0.60, R2 = 0.36, p < 0.009) (Figure 2).

Regulation (values) of MPP

10) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0 Pain Relevance 0

We found that the MPP and PTI values before and after treatment did not correlate to the subjective outcome rating or pain improvement.

Regulation (values) of MPP associated with pain

11) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.50 Pain Relevance 0.54

Whatever the determinants of cholesterol metabolism alterations in DSS patients, our results reinforce interest in considering sub-fractions and total cholesterol as putative biomarkers of DSS [115].

Regulation (alterations) of DSS associated with dengue hemorrhagic fever and disorder of lipid metabolism

12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.62 Pain Relevance 0.07

This type of supervised comparison was used to identify genes that were significantly up-regulated in DF, DHF and DSS patient samples relative to convalescent patient samples.

Regulation (regulated) of DSS associated with dengue and dengue hemorrhagic fever

13) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 0.56 Pain Relevance 0

General Comments

This test has worked.