INT164519

Context Info Confidence 0.39 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.22 Pain Relevance 0.19

isomerase activity (FKBP1A) protein folding (FKBP1A) cytosol (FKBP1A) signal transduction (FKBP1A) cytoplasm (FKBP1A) signal transducer activity (FKBP1A)

Anatomy Link Frequency T-cell 1 FKBP1A (Homo sapiens)

Pain Link Frequency Relevance Heat Immobilon 2 92.64 Kinase C 2 80.56 Kinase C inhibitor 1 74.24 psoriasis 1 53.92 headache 1 42.64 antagonist 10 5.00 opiate 9 5.00 mu opioid receptor 5 5.00 Opioid 5 5.00 Morphine 3 5.00

Disease Link Frequency Relevance Heat Organ Transplantation 2 96.12 Psoriasis 1 53.92 Gastrointestinal Disease 1 45.12 Headache 1 42.64 Cancer 6 5.00 Renal Cancer 2 5.00 Pain 2 5.00 Disease 2 5.00 Anaemia 1 5.00 Thrombocytopenia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transfection of siRNA against mTOR, Src, Rictor, FKBP12 and Akt

Gene_expression (Transfection) of FKBP12

1) Confidence 0.39 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.05

Calcineurin inhibitor such as ciclosporin A inhibits T-cell activation by interfering with the cytosolic protein cyclophilin (immunophilin).

Gene_expression (interfering) of immunophilin in T-cell

2) Confidence 0.10 Published 2009 Journal Clin Transplant Section Abstract Doc Link 19930311 Disease Relevance 0.22 Pain Relevance 0.14

General Comments

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