INT164519

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (FKBP1A) protein folding (FKBP1A) cytosol (FKBP1A)
signal transduction (FKBP1A) cytoplasm (FKBP1A) signal transducer activity (FKBP1A)
Anatomy Link Frequency
T-cell 1
FKBP1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 2 92.64 High High
Kinase C 2 80.56 Quite High
Kinase C inhibitor 1 74.24 Quite High
psoriasis 1 53.92 Quite High
headache 1 42.64 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
opiate 9 5.00 Very Low Very Low Very Low
mu opioid receptor 5 5.00 Very Low Very Low Very Low
Opioid 5 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 2 96.12 Very High Very High Very High
Psoriasis 1 53.92 Quite High
Gastrointestinal Disease 1 45.12 Quite Low
Headache 1 42.64 Quite Low
Cancer 6 5.00 Very Low Very Low Very Low
Renal Cancer 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Thrombocytopenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of siRNA against mTOR, Src, Rictor, FKBP12 and Akt
Gene_expression (Transfection) of FKBP12
1) Confidence 0.39 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.05
Calcineurin inhibitor such as ciclosporin A inhibits T-cell activation by interfering with the cytosolic protein cyclophilin (immunophilin).
Gene_expression (interfering) of immunophilin in T-cell
2) Confidence 0.10 Published 2009 Journal Clin Transplant Section Abstract Doc Link 19930311 Disease Relevance 0.22 Pain Relevance 0.14

General Comments

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