INT16452

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 8.43
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPIND1)
Anatomy Link Frequency
coronary artery 3
plasma 2
venous sinus 1
SERPIND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 7 99.24 Very High Very High Very High
cva 27 97.92 Very High Very High Very High
Demyelination 8 78.16 Quite High
abdominal pain 4 76.80 Quite High
Spinal cord 6 60.40 Quite High
imagery 5 29.44 Quite Low
Pain 11 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 5 99.32 Very High Very High Very High
Cv General 3 Under Development 20 99.24 Very High Very High Very High
Vasculitis 4 99.02 Very High Very High Very High
Coronary Artery Disease 7 98.44 Very High Very High Very High
Intracranial Sinus Thrombosis 4 97.32 Very High Very High Very High
Thrombosis 30 94.20 High High
Infection 25 93.24 High High
Cv Unclassified Under Development 21 93.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 85 92.84 High High
Pressure And Volume Under Development 4 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin.
Negative_regulation (inhibitor) of HCII in plasma
1) Confidence 0.59 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.15 Pain Relevance 0.08
To understand the molecular mechanism for HCII deficiency in a patient with reduced circulating HCII antigen, we studied a Japanese patient with type I HCII deficiency who suffered from angina pectoris and coronary artery disease.
Negative_regulation (reduced) of HCII in coronary artery associated with angina and coronary artery disease
2) Confidence 0.59 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.19 Pain Relevance 0.10
To understand the molecular mechanism for HCII deficiency in a patient with reduced circulating HCII antigen, we studied a Japanese patient with type I HCII deficiency who suffered from angina pectoris and coronary artery disease.
Negative_regulation (deficiency) of HCII in coronary artery associated with angina and coronary artery disease
3) Confidence 0.59 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.19 Pain Relevance 0.09
Laboratory investigations performed after thrombotic episodes and repeated 5 years later evidenced a type 1 Heparin Cofactor II deficiency (HCII Ag by EID: 40 percent; functional Tollefsen's method: 60 percent).
Negative_regulation (deficiency) of HCII
4) Confidence 0.59 Published 1991 Journal Presse Med Section Abstract Doc Link 1831893 Disease Relevance 1.33 Pain Relevance 0.28
Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin.
Negative_regulation (inhibitor) of cofactor II in plasma
5) Confidence 0.51 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.15 Pain Relevance 0.08
Vascular injury may act as a triggering factor in patients with HCII deficiency.
Negative_regulation (deficiency) of HCII associated with vasculitis
6) Confidence 0.51 Published 1991 Journal Presse Med Section Abstract Doc Link 1831893 Disease Relevance 1.18 Pain Relevance 0.23
Laboratory investigations performed after thrombotic episodes and repeated 5 years later evidenced a type 1 Heparin Cofactor II deficiency (HCII Ag by EID: 40 percent; functional Tollefsen's method: 60 percent).
Negative_regulation (deficiency) of Heparin Cofactor II
7) Confidence 0.51 Published 1991 Journal Presse Med Section Abstract Doc Link 1831893 Disease Relevance 1.33 Pain Relevance 0.28
This is the first reported case of HCII deficiency associated with mesenteric infarction and cerebral thrombophlebitis.
Negative_regulation (deficiency) of HCII associated with cv general 4 under development and cva
8) Confidence 0.43 Published 1991 Journal Presse Med Section Abstract Doc Link 1831893 Disease Relevance 1.26 Pain Relevance 0.27
To understand the molecular mechanism for HCII deficiency in a patient with reduced circulating HCII antigen, we studied a Japanese patient with type I HCII deficiency who suffered from angina pectoris and coronary artery disease.
Negative_regulation (deficiency) of HCII in coronary artery associated with angina and coronary artery disease
9) Confidence 0.43 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.20 Pain Relevance 0.10
Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji).
Negative_regulation (deficiency) of cofactor II
10) Confidence 0.38 Published 1996 Journal Blood Section Title Doc Link 8562924 Disease Relevance 0.17 Pain Relevance 0.09
Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji).
Negative_regulation (deficiency) of cofactor II
11) Confidence 0.38 Published 1996 Journal Blood Section Title Doc Link 8562924 Disease Relevance 0.17 Pain Relevance 0.09
The potential contributing factors that have been identified are: (1) anticardiolipin antibodies; (2) low levels of protein S; (3) deficiency of heparin cofactor 2; and (4) vasculopathy.[1-3] There were 3 cases of cortical venous sinus thrombosis.
Negative_regulation (deficiency) of heparin cofactor 2 in venous sinus associated with intracranial sinus thrombosis
12) Confidence 0.13 Published 2005 Journal J Int AIDS Soc Section Body Doc Link PMC2740789 Disease Relevance 2.03 Pain Relevance 0.16
Heparan and dermatan sulphate are thrombin inhibitors acting through complementary pathways, antithrombin (AT), and heparin cofactor II, respectively [1].
Negative_regulation (inhibitors) of heparin cofactor II
13) Confidence 0.02 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989756 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox