INT164533

Context Info Confidence 0.46 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.09 Pain Relevance 1.06

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)

Anatomy Link Frequency sciatic nerve 2 adipose tissue 2 regulatory T cells 2 Il10 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory response 8 100.00 Eae 50 98.72 Inflammation 56 98.68 Sciatic nerve 21 98.28 Arthritis 59 98.16 cytokine 83 77.84 complementary and alternative medicine 8 63.76 Chronic pancreatitis 2 50.00 rheumatoid arthritis 16 44.92 Neuropathic pain 19 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 62 100.00 Obesity 40 100.00 Injury 61 98.72 Arthritis 69 98.68 Stress 4 74.04 Autoimmune Disease 3 70.56 Disease 13 50.00 Pancreatitis 3 50.00 Experimental Arthritis 3 50.00 Rheumatoid Arthritis 16 44.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Significant changes of IL-10 protein levels were also induced in C7-C8 DRG by the unilateral CCI of the sciatic nerve.

Positive_regulation (induced) of Regulation (changes) of IL-10 in sciatic nerve associated with eae and sciatic nerve

1) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.62 Pain Relevance 0.43

However, endurance exercise programs induce an anti-inflammatory response in the adipose tissue and increase IL-10 levels, leading to a protective effect [10].

Positive_regulation (induce) of Regulation (response) of IL-10 in adipose tissue associated with inflammatory response and obesity

2) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.18 Pain Relevance 0.31

inhibits the IL-17 response, which in turn cooperates with the enhanced IL-10 response to downmodulate the severity of inflammatory arthritis in LEW rats.

Positive_regulation (enhanced) of Regulation (response) of IL-10 associated with inflammation and arthritis

3) Confidence 0.19 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.28 Pain Relevance 0.32

Pancreatitis lesions, in comparison with pancreatic carcinomas, contained increased concentrations of IL-10 and reduced levels of IFN-gamma, suggesting pancreatitis-specific activity of regulatory T cells in situ.

Positive_regulation (increased) of Regulation (concentrations) of IL-10 in regulatory T cells

4) Confidence 0.13 Published 2010 Journal Gastroenterology Section Body Doc Link 19931255 Disease Relevance 0 Pain Relevance 0

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