INT164533

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.09
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
sciatic nerve 2
adipose tissue 2
regulatory T cells 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 8 100.00 Very High Very High Very High
Eae 50 98.72 Very High Very High Very High
Inflammation 56 98.68 Very High Very High Very High
Sciatic nerve 21 98.28 Very High Very High Very High
Arthritis 59 98.16 Very High Very High Very High
cytokine 83 77.84 Quite High
complementary and alternative medicine 8 63.76 Quite High
Chronic pancreatitis 2 50.00 Quite Low
rheumatoid arthritis 16 44.92 Quite Low
Neuropathic pain 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 100.00 Very High Very High Very High
Obesity 40 100.00 Very High Very High Very High
Injury 61 98.72 Very High Very High Very High
Arthritis 69 98.68 Very High Very High Very High
Stress 4 74.04 Quite High
Autoimmune Disease 3 70.56 Quite High
Disease 13 50.00 Quite Low
Pancreatitis 3 50.00 Quite Low
Experimental Arthritis 3 50.00 Quite Low
Rheumatoid Arthritis 16 44.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant changes of IL-10 protein levels were also induced in C7-C8 DRG by the unilateral CCI of the sciatic nerve.
Positive_regulation (induced) of Regulation (changes) of IL-10 in sciatic nerve associated with eae and sciatic nerve
1) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.62 Pain Relevance 0.43
However, endurance exercise programs induce an anti-inflammatory response in the adipose tissue and increase IL-10 levels, leading to a protective effect [10].
Positive_regulation (induce) of Regulation (response) of IL-10 in adipose tissue associated with inflammatory response and obesity
2) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.18 Pain Relevance 0.31
inhibits the IL-17 response, which in turn cooperates with the enhanced IL-10 response to downmodulate the severity of inflammatory arthritis in LEW rats.
Positive_regulation (enhanced) of Regulation (response) of IL-10 associated with inflammation and arthritis
3) Confidence 0.19 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.28 Pain Relevance 0.32
Pancreatitis lesions, in comparison with pancreatic carcinomas, contained increased concentrations of IL-10 and reduced levels of IFN-gamma, suggesting pancreatitis-specific activity of regulatory T cells in situ.
Positive_regulation (increased) of Regulation (concentrations) of IL-10 in regulatory T cells
4) Confidence 0.13 Published 2010 Journal Gastroenterology Section Body Doc Link 19931255 Disease Relevance 0 Pain Relevance 0

General Comments

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