INT164544

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
megakaryoblasts 2
microglia 2
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 1 99.98 Very High Very High Very High
Potency 10 96.00 Very High Very High Very High
agonist 21 95.68 Very High Very High Very High
Peripheral nerve injury 2 92.00 High High
medulla 14 91.36 High High
spinal dorsal horn 1 91.00 High High
trigeminal ganglion 39 90.72 High High
Spinal cord 10 90.24 High High
Neuropathic pain 6 89.72 High High
Pain 16 84.96 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 16 97.84 Very High Very High Very High
Hypertrophy 2 95.60 Very High Very High Very High
Coronary Artery Disease 44 93.64 High High
Nervous System Injury 8 92.00 High High
Ganglion Cysts 39 90.72 High High
Neuropathic Pain 18 89.72 High High
Pain 26 84.96 Quite High
Disease 8 81.44 Quite High
Atherosclerosis 11 80.32 Quite High
Disorder Of Lipid Metabolism 6 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, nicotine upregulates the expression of P2Y12 receptors on vascular cells and megakaryoblasts, and smokers exhibit higher P2Y12 expression [21].
Positive_regulation (upregulates) of Gene_expression (expression) of P2Y12 in megakaryoblasts associated with nicotine addiction and nicotine
1) Confidence 0.67 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 1.29 Pain Relevance 0.11
For GFAP-, Iba1- and P2Y12- receptor immunostaining, the mean pixel intensity values were expressed as fold increase compared to the contralateral side of saline injected animals set to 1.0.
Positive_regulation (increase) of Gene_expression (expressed) of P2Y12
2) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.36 Pain Relevance 0.44
These activated microglia upregulate expression of P2X/Y receptors (e.g., P2X4 and P2Y12).
Positive_regulation (upregulate) of Gene_expression (expression) of P2Y12 in microglia
3) Confidence 0.24 Published 2010 Journal Brain Res Rev Section Abstract Doc Link 19931560 Disease Relevance 0.76 Pain Relevance 0.66
To examine whether the receptor protein serves as a direct target of this action, human P2Y12 receptor was stably transfected into CHO cells.
Positive_regulation (transfected) of Gene_expression (transfected) of P2Y12
4) Confidence 0.18 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0.42

General Comments

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