INT164558

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.55
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PERP) Golgi apparatus (PERP) nucleolus (PERP)
plasma membrane (PERP) nucleus (PERP) cytoplasm (PERP)
Anatomy Link Frequency
thyroid 1
nerve 1
keratinocytes 1
PERP (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 141 100.00 Very High Very High Very High
Inflammation 2 98.72 Very High Very High Very High
Lasting pain 6 98.08 Very High Very High Very High
hyperexcitability 6 97.56 Very High Very High Very High
Spontaneous pain 2 97.44 Very High Very High Very High
Pain 5 96.68 Very High Very High Very High
Nerve growth factor 6 95.96 Very High Very High Very High
Action potential 2 86.16 High High
positron emission tomography 21 35.44 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 24 99.98 Very High Very High Very High
Neuropathic Pain 2 99.32 Very High Very High Very High
Wound Healing 2 98.96 Very High Very High Very High
INFLAMMATION 2 98.72 Very High Very High Very High
Thyroid Neoplasm 96 98.34 Very High Very High Very High
Pain 13 98.08 Very High Very High Very High
Disease 63 68.48 Quite High
Metastasis 42 56.48 Quite High
Recurrence 15 39.76 Quite Low
Cancer 36 26.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients randomized to THW discontinued levothyroxine for 5 weeks, then received the RAI dose.
THW Binding (randomized) of associated with withdrawal
1) Confidence 0.14 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0 Pain Relevance 0.27
Further, the interpretation of this literature is difficult given the relative lack of comparable data for the efficacy of RAI therapy prepared by THW, with reports ranging from 20% to 90% (Maxon et al 1992; Pacini et al 1994; Alzahrani et al 2002; Robbins et al 2002a; Dam et al 2004; Rosario et al 2004; Kloos and Mazzaferri 2005).
THW Binding (prepared) of associated with withdrawal
2) Confidence 0.14 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.12 Pain Relevance 0.16
Recognition of the ability of rhTSH-stimulated Tg measurement to identify residual/recurrent thyroid cancer with high accuracy and the potential for avoiding the morbidity of hypothyroidism associated with THW has led to a shift in the paradigm for the follow-up evaluation of patients with thyroid cancer.
THW Binding (associated) of in thyroid associated with thyroid neoplasm, thyroid disease and withdrawal
3) Confidence 0.14 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.51 Pain Relevance 0.08
We studied the interaction of human keratinocytes (hKTs) and regenerating afferent nerve fibers by transplanting hKTs into a ligated and transected peripheral nerve.
keratinocytes Binding (interaction) of in nerve
4) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 19932564 Disease Relevance 0.37 Pain Relevance 0.45
The results demonstrate that an interaction between injured/regenerating nerve fibers and keratinocytes such as may occur during wound healing, results in afferent hyperexcitability and pain.
keratinocytes Binding (interaction) of in keratinocytes associated with pain, wound healing and hyperexcitability
5) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 19932564 Disease Relevance 0.55 Pain Relevance 0.71

General Comments

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