INT164583

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 22.45
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
endothelial cells 3
fibroblasts 3
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 99.98 Very High Very High Very High
rheumatoid arthritis 120 99.84 Very High Very High Very High
Osteoarthritis 63 96.80 Very High Very High Very High
cINOD 7 60.08 Quite High
palliative 24 56.28 Quite High
Arthritis 81 50.00 Quite Low
Kinase C 7 41.48 Quite Low
chemokine 22 37.76 Quite Low
cytokine 19 29.72 Quite Low
Inflammatory mediators 9 21.52 Low Low
Disease Link Frequency Relevance Heat
Carcinoma 1128 100.00 Very High Very High Very High
Apoptosis 1418 99.98 Very High Very High Very High
Rheumatoid Arthritis 120 99.84 Very High Very High Very High
Cholangiocarcinoma 25 99.48 Very High Very High Very High
Cancer 388 99.00 Very High Very High Very High
Targeted Disruption 49 97.52 Very High Very High Very High
Malignant Neoplastic Disease 19 96.84 Very High Very High Very High
Osteoarthritis 63 96.80 Very High Very High Very High
Leukemia 59 94.12 High High
Death 96 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we applied RNA interference to downregulate Mcl-1 expression in the HCC cell line Huh7.
Negative_regulation (downregulate) of Gene_expression (expression) of Mcl-1 associated with carcinoma
1) Confidence 0.56 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.29 Pain Relevance 0
Only two genes showed differential expression in nearly all tumors, Bik gene was overexpressed in 14/15 samples and MCL-1 gene expression was diminished or absent in the same number of tumors.
Negative_regulation (diminished) of Neg (absent) Gene_expression (expression) of MCL-1 associated with cancer
2) Confidence 0.53 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.20 Pain Relevance 0
Thus, interference with Mcl-1 expression is an option for the treatment of patients with HCC.


Negative_regulation (interference) of Gene_expression (expression) of Mcl-1 associated with carcinoma
3) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.70 Pain Relevance 0
Next, we analyzed whether interference with Mcl-1 expression could possibly influence the apoptosis sensitivity of HCC cell lines.
Negative_regulation (interference) of Gene_expression (expression) of Mcl-1 associated with carcinoma and apoptosis
4) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.96 Pain Relevance 0.06
In the current study, transfection of chemically synthesized siRNA had a fast inhibitory effect on Mcl-1 expression in HCC cells in vitro. 24 h after transfection of HCC cells with siRNA, Mcl-1 expression was profoundly reduced. siRNA can also be applied in animals in vivo by intravenous or local injection.
Negative_regulation (effect) of Gene_expression (expression) of Mcl-1 associated with carcinoma
5) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.10 Pain Relevance 0
RNA interference efficiently downregulated Mcl-1 expression in HCC cells.
Negative_regulation (downregulated) of Gene_expression (expression) of Mcl-1 associated with carcinoma
6) Confidence 0.42 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1601962 Disease Relevance 1.68 Pain Relevance 0
In contrast to Hep3B, even prolonged incubation of Huh7 cells with the PI3K inhibitor LY29004 for up to 24 h did not markedly reduce Mcl-1 expression in Huh7 cells (Fig. 2A).
Neg (not) Negative_regulation (reduce) of Gene_expression (expression) of Mcl-1
7) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.91 Pain Relevance 0
In the current study, transfection of chemically synthesized siRNA had a fast inhibitory effect on Mcl-1 expression in HCC cells in vitro. 24 h after transfection of HCC cells with siRNA, Mcl-1 expression was profoundly reduced. siRNA can also be applied in animals in vivo by intravenous or local injection.
Negative_regulation (effect) of Gene_expression (expression) of Mcl-1 associated with carcinoma
8) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.13 Pain Relevance 0
The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.
Negative_regulation (downregulation) of Gene_expression (effect) of Mcl-1 associated with carcinoma and apoptosis
9) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.93 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Negative_regulation (detected) of Gene_expression (expression) of Mcl-1
10) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
Treatment of Huh7 cells with a Raf I-kinase inhibitor neither altered Mcl-1 expression nor influenced sensitivity towards chemotherapeutic drug-induced apoptosis (Fig. 2A, and data not shown).
Neg (neither) Negative_regulation (inhibitor) of Gene_expression (expression) of Mcl-1 associated with apoptosis
11) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.06 Pain Relevance 0
Transfection with Mcl-1 specific siRNA led to a profound decrease of Mcl-1 expression on mRNA as well as protein level already 24 h after transfection and continues for at least 72 h (Fig. 3A).
Negative_regulation (decrease) of Gene_expression (expression) of Mcl-1
12) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.33 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Negative_regulation (detected) of Gene_expression (transfection) of Mcl-1 siRNA
13) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.94 Pain Relevance 0
Enforced miR-29b expression reduced Mcl1 protein expression in the KMCH cholangiocarcinoma cells, thus miR-29 was an endogenous regulator of Mcl1 protein expression [31].
Negative_regulation (reduced) of Gene_expression (expression) of Mcl1 associated with cholangiocarcinoma
14) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.99 Pain Relevance 0
In contrast, aspirin decreased the protein levels of Mcl-1.
Negative_regulation (decreased) of Gene_expression (levels) of Mcl-1 associated with aspirin
15) Confidence 0.36 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.09 Pain Relevance 0.62
Importantly, EGCG specifically abrogated Mcl-1 expression in RA synovial fibroblasts and affected Mcl-1 expression to a lesser extent in OA synovial fibroblasts, normal synovial fibroblasts, and endothelial cells.
Negative_regulation (abrogated) of Gene_expression (expression) of Mcl-1 in endothelial cells associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.51 Pain Relevance 0.43
Our recent study to evaluate the efficacy of EGCG in downregulating Mcl-1 expression showed that, in RA synovial fibroblasts, EGCG inhibits constitutive and TNF?
Negative_regulation (downregulating) of Gene_expression (expression) of Mcl-1 in fibroblasts associated with rheumatoid arthritis
17) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.35 Pain Relevance 0.39
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
Negative_regulation (override) of Gene_expression (levels) of Mcl-1 associated with apoptosis
18) Confidence 0.11 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.85 Pain Relevance 0
Importantly, EGCG specifically abrogated Mcl-1 expression in RA synovial fibroblasts and affected Mcl-1 expression to a lesser extent in OA synovial fibroblasts, normal synovial fibroblasts, and endothelial cells.
Negative_regulation (abrogated) of in fibroblasts Gene_expression (expression) of Mcl-1 in endothelial cells associated with rheumatoid arthritis and osteoarthritis
19) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.51 Pain Relevance 0.43

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