INT164586

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.56
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK10) nucleoplasm (MAPK10) signal transduction (MAPK10)
mitochondrion (MAPK10) plasma membrane (MAPK10) nucleus (MAPK10)
MAPK10 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 99.98 Very High Very High Very High
COX2 1 97.44 Very High Very High Very High
cINOD 1 75.16 Quite High
agonist 33 50.00 Quite Low
Bile 2 38.40 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 53 99.58 Very High Very High Very High
Drug Induced Neurotoxicity 1 99.46 Very High Very High Very High
Leukemia 6 97.56 Very High Very High Very High
Hepatocellular Cancer 8 89.44 High High
Lung Cancer 13 83.36 Quite High
Bladder Cancer 2 83.36 Quite High
Toxicity 11 78.84 Quite High
INFLAMMATION 5 74.92 Quite High
Chronic Lymphoid Leukemia 1 55.68 Quite High
Hepatotoxicity 9 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although aspirin induced p38 MAPK and c-Jun N-terminal kinase activation, selective inhibitors of these kinases did not inhibit aspirin-induced apoptosis.
Positive_regulation (induced) of c-Jun N-terminal kinase associated with aspirin and apoptosis
1) Confidence 0.29 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.12 Pain Relevance 0.56
Apoptosis was associated with activation of both c-Jun N-terminal protein kinase and p38 kinase and overexpression of proapoptotic proteins and cyclooxygenase 2 (COX-2) [77, 83].
Positive_regulation (activation) of c-Jun N-terminal protein kinase associated with cox2 and apoptosis
2) Confidence 0.22 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.81 Pain Relevance 0.05
Namgung and Xia have reported that the neurotoxicity of arsenite may cause the activation of p38 and c-Jun N- terminal kinase 3 (JNK3) and mitogen-activated protein kinases (MAPKs), which are involved in the apoptosis process [6,32].
Positive_regulation (activation) of JNK3 associated with drug induced neurotoxicity and apoptosis
3) Confidence 0.20 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 0.63 Pain Relevance 0

General Comments

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