INT164587

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 94
Total Number 94
Disease Relevance 124.05
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
liver 3
fibroblasts 3
endothelial cells 2
hepatocytes 1
cleavage 1
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 196 100.00 Very High Very High Very High
rheumatoid arthritis 280 99.84 Very High Very High Very High
aspirin 17 99.54 Very High Very High Very High
Osteoarthritis 147 99.08 Very High Very High Very High
Inflammatory mediators 43 97.48 Very High Very High Very High
imagery 44 97.16 Very High Very High Very High
Nerve growth factor 27 91.68 High High
ischemia 6 85.48 High High
metalloproteinase 172 82.24 Quite High
palliative 91 76.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5611 100.00 Very High Very High Very High
Carcinoma 4257 100.00 Very High Very High Very High
Obesity 2482 100.00 Very High Very High Very High
Cancer 2200 100.00 Very High Very High Very High
INFLAMMATION 260 100.00 Very High Very High Very High
Diabetes Mellitus 29 99.96 Very High Very High Very High
Breast Cancer 81 99.92 Very High Very High Very High
Targeted Disruption 182 99.88 Very High Very High Very High
Lung Cancer 718 99.84 Very High Very High Very High
Rheumatoid Arthritis 280 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M, 1–6 h) influenced Mcl-1 expression in Huh7 cells (data not shown).
Gene_expression (expression) of Mcl-1
1) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.85 Pain Relevance 0
In this study, we analyzed the relevance of Mcl-1 expression for apoptosis induced by different kinase inhibitors.
Gene_expression (expression) of Mcl-1 associated with apoptosis
2) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.83 Pain Relevance 0
Transfection with Mcl-1 specific siRNA led to a profound decrease of Mcl-1 expression on mRNA as well as protein level already 24 h after transfection and continues for at least 72 h (Fig. 3A).
Gene_expression (expression) of Mcl-1
3) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.32 Pain Relevance 0
We have already shown that the PI3K/Akt pathway induces Mcl-1 expression in human hepatocytes [33].
Gene_expression (expression) of Mcl-1 in hepatocytes
4) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.23 Pain Relevance 0
g/ml, 24 h) was enhanced from 15% (cells transfected with control siRNA) to 32% (cells transfected with Mcl-1 siRNA, p < 0.001).
Gene_expression (transfected) of Mcl-1 siRNA
5) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.70 Pain Relevance 0
Neither Mcl-1 expression nor chemotherapeutic drug-induced apoptosis (as tested for cisplatin, epirubicin and 5-FU) was influenced by MEK1 inhibition (Fig. 2A, 2B, and data not shown).
Gene_expression (expression) of Mcl-1 associated with apoptosis
6) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.98 Pain Relevance 0
In this study, we first tested the sensitivity of Mcl-1 expressing HCC cells to a panel of chemotherapeutic drugs.
Gene_expression (expressing) of Mcl-1 associated with carcinoma
7) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.89 Pain Relevance 0
Treatment of Huh7 cells with a Raf I-kinase inhibitor neither altered Mcl-1 expression nor influenced sensitivity towards chemotherapeutic drug-induced apoptosis (Fig. 2A, and data not shown).
Gene_expression (expression) of Mcl-1 associated with apoptosis
8) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.05 Pain Relevance 0
Sensitizing HCC cells towards chemotherapeutic drug-induced apoptosis by RNAi of Mcl-1 expression
Gene_expression (expression) of Mcl-1 associated with carcinoma and apoptosis
9) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.27 Pain Relevance 0
In this study, we applied RNA interference to downregulate Mcl-1 expression in the HCC cell line Huh7.
Gene_expression (expression) of Mcl-1 associated with carcinoma
10) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.28 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Gene_expression (expression) of Mcl-1
11) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Gene_expression (transfection) of Mcl-1 siRNA
12) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
Transfection with Mcl-1 specific siRNA led to a profound decrease of Mcl-1 expression on mRNA as well as protein level already 24 h after transfection and continues for at least 72 h (Fig. 3A).
Gene_expression (Transfection) of Mcl-1
13) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.33 Pain Relevance 0
Enforced miR-29b expression reduced Mcl1 protein expression in the KMCH cholangiocarcinoma cells, thus miR-29 was an endogenous regulator of Mcl1 protein expression [31].
Gene_expression (expression) of Mcl1 associated with cholangiocarcinoma
14) Confidence 0.70 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.99 Pain Relevance 0
Only two genes showed differential expression in nearly all tumors, Bik gene was overexpressed in 14/15 samples and MCL-1 gene expression was diminished or absent in the same number of tumors.
Neg (absent) Gene_expression (expression) of MCL-1 associated with cancer
15) Confidence 0.70 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.20 Pain Relevance 0
The widely used mTOR inhibitor rapamycin did not influence Mcl-1 expression or apoptosis sensitivity of Huh7 cells (Fig. 2A, 2B).


Gene_expression (expression) of Mcl-1 associated with apoptosis
16) Confidence 0.65 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.23 Pain Relevance 0
The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.
Gene_expression (effect) of Mcl-1 associated with carcinoma and apoptosis
17) Confidence 0.65 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
Several biomolecular studies in humans have shown that EAT is metabolically active and an important source of both pro-inflammatory adipokines, such as tumor necrosis factor-?
Gene_expression (source) of EAT associated with necrosis, inflammation, cancer and obesity
18) Confidence 0.64 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.40 Pain Relevance 0.24
Enforced miR-29b expression reduced Mcl1 protein expression in the KMCH cholangiocarcinoma cells, thus miR-29 was an endogenous regulator of Mcl1 protein expression [31].
Gene_expression (expression) of Mcl1 associated with cholangiocarcinoma
19) Confidence 0.61 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.94 Pain Relevance 0
In the lower part of the same Figure, we showed the gene expression pattern of eight genes related with apoptotic process obtained from each tumor, showing changes across all samples but exposing the possible relation between pro-apoptotic (BAK, BAX, BIK, BAD) and anti-apoptotic genes (BCL2, BCLW, MCL1, BCL2- A1).
Gene_expression (expression) of MCL1 associated with cancer and apoptosis
20) Confidence 0.61 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.08 Pain Relevance 0.04

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