INT164588

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 14.09
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 48 99.54 Very High Very High Very High
cINOD 8 98.44 Very High Very High Very High
COX-2 inhibitor 6 98.00 Very High Very High Very High
Inflammation 27 82.88 Quite High
palliative 6 75.20 Quite High
cytokine 4 35.12 Quite Low
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 461 100.00 Very High Very High Very High
Obesity 407 100.00 Very High Very High Very High
Carcinoma 284 99.52 Very High Very High Very High
Squamous Cell Carcinoma 10 99.12 Very High Very High Very High
Metabolic Syndrome 108 98.56 Very High Very High Very High
Leukemia 17 98.48 Very High Very High Very High
Chronic Lymphoid Leukemia 4 97.20 Very High Very High Very High
Cancer 269 96.92 Very High Very High Very High
Repression 2 96.44 Very High Very High Very High
Stress 1 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensitizing effect of Mcl-1 RNA interference was observed in combination with all chemotherapeutic agents tested in this setting (epirubicin, 5-FU/VA, mitomycin C and cisplatin) (Fig. 5A).
Regulation (effect) of Mcl-1 RNA
1) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.68 Pain Relevance 0
This alteration of the Mcl-1/Noxa balance was also found in other leukemia cell lines and primary chronic lymphocytic leukemia cells (CLL).
Regulation (alteration) of Mcl-1 associated with chronic lymphoid leukemia and leukemia
2) Confidence 0.37 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.06 Pain Relevance 0.61
Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT.
Regulation (regulation) of Mcl-1 associated with squamous cell carcinoma, aspirin and apoptosis
3) Confidence 0.35 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 20116423 Disease Relevance 0.67 Pain Relevance 0.69
Importantly, pretreatment with z-VAD-fmk, a pan-caspase inhibitor blocked the aspirin-induced apoptosis and Mcl-1 down-regulation in YD-8 cells.
Regulation (regulation) of Mcl-1 associated with aspirin and apoptosis
4) Confidence 0.35 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.62 Pain Relevance 0.60
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Regulation (regulation) of Mcl-1 associated with aspirin
5) Confidence 0.35 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.61
The apoptotic regulatory proteins, which were analyzed, include the following: Bad, Bak, Mcl-1, Bcl-2, Bcl-x, Mdm-2, and Bax.
Regulation (following) of Mcl-1 associated with apoptosis
6) Confidence 0.31 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.52 Pain Relevance 0
In this study, we first sought to explore the sensitivity of Mcl-1 expressing HCC cell lines to chemotherapeutic drug-induced apoptosis.
Regulation (sensitivity) of Mcl-1 associated with carcinoma and apoptosis
7) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.00 Pain Relevance 0.08
Antisense strategies targeting anti-apoptotic Bcl-2 family proteins including Mcl-1 have been successfully applied in various human malignancies in vitro and in vivo [25,58,59].
Regulation (targeting) of Mcl-1 associated with apoptosis
8) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0
The median EAT thickness values for subjects with 0, 1, 2, 3, 4, or 5 MS components were 2.5, 2.3, 3.3, 3.0, 3.0, and 4.5 mm, respectively.
Regulation (values) of EAT associated with obesity and metabolic syndrome
9) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.79 Pain Relevance 0
The median EAT thickness values for those with 0, 1, 2, 3, 4, or 5 MS components were 1.3, 1.7, 2.0, 3.5, 3.5, and 3.2 mm, respectively.
Regulation (values) of EAT associated with obesity and metabolic syndrome
10) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.67 Pain Relevance 0
In contrast, we have not observed modulation of c-myc, MCL-1 or cIAP1 or cIAP2 in our system, using HCT116 cells which are bax proficient.
Regulation (modulation) of MCL-1
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.76 Pain Relevance 0.04
Because Mcl-1 is a target for ubiquitination, proteasome inhibition increases levels of Mcl-1.
Regulation (target) of Mcl-1
12) Confidence 0.07 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.78 Pain Relevance 0

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