INT164595

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.03
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN2)
Anatomy Link Frequency
Neutrophil 3
proximal 2
blood 1
Horn 1
liver 1
LCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 5 99.88 Very High Very High Very High
cytokine 10 82.34 Quite High
Inflammation 42 82.28 Quite High
anesthesia 1 82.08 Quite High
imagery 81 73.24 Quite High
addiction 3 70.48 Quite High
Inflammatory response 10 68.48 Quite High
ischemia 1 57.00 Quite High
fibrosis 14 16.28 Low Low
chemokine 4 15.92 Low Low
Disease Link Frequency Relevance Heat
Arthritis 2 99.88 Very High Very High Very High
Albuminuria 12 99.82 Very High Very High Very High
Systemic Lupus Erythematosus 86 99.52 Very High Very High Very High
Disease 171 99.36 Very High Very High Very High
Renal Disease 146 98.88 Very High Very High Very High
Injury 28 98.68 Very High Very High Very High
Sepsis 10 96.72 Very High Very High Very High
Stress 47 95.12 Very High Very High Very High
Bronchiolitis Obliterans 44 95.12 Very High Very High Very High
Juvenile Chronic Polyarthritis 3 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily for which a variety of functions such as cellular protection against oxidative stress have been reported.
Lcn2 Binding (associated) of in Neutrophil associated with stress
1) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.27 Pain Relevance 0
Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily for which a variety of functions such as cellular protection against oxidative stress have been reported.
NGAL Binding (associated) of in Neutrophil associated with stress
2) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.28 Pain Relevance 0
Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily for which a variety of functions such as cellular protection against oxidative stress have been reported.
Lipocalin Binding (associated) of in Neutrophil associated with stress
3) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.27 Pain Relevance 0
To our knowledge, there have been no reports on the expression change of NGAL and its interaction with SM-induced pulmonary complications of delayed form.
NGAL Neg (no) Binding (interaction) of
4) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.34 Pain Relevance 0.09
uNGAL levels correlated with urine protein-to-creatinine ratios and were associated with renal SLE disease activity scores only, but not with global damage or extrarenal disease activity scores.
uNGAL Binding (associated) of in urine associated with disease and systemic lupus erythematosus
5) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.63 Pain Relevance 0.15
In addition, B2M and H-FABP were associated inversely with measured GFR and effective renal blood flow independent of albuminuria; KIM-1, NGAL, and MCP-1 were associated positively with total renal volume independent of albuminuria [54].
NGAL Binding (associated) of in blood associated with albuminuria
6) Confidence 0.15 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.81 Pain Relevance 0.08
-D-glucosammide (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) as markers for damage of the proximal tubule; urinary heart-type fatty acid binding protein (HFABP) as a marker for damage of the distal tubule.
NGAL Binding (associated) of in proximal
7) Confidence 0.15 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.64 Pain Relevance 0.08
-D-glucosammide (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) as markers for damage of the proximal tubule; urinary heart-type fatty acid binding protein (HFABP) as a marker for damage of the distal tubule.
lipocalin Binding (associated) of in proximal
8) Confidence 0.13 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.63 Pain Relevance 0.08
It is by now well established that—while a ‘cytokine storm’ (Huang et al. 2005; Sriskandan and Altmann 2008; Stacey et al. 2009; Suntharalingam et al. 2006; Wang and Ma 2008; Woo et al. 2010) is an important part of the aetiology of sepsis/septic shock—these phenomena are associated with the hyperproduction of ROSs (Abdelrahman et al. 2005; Andrades et al. 2005; Bulger and Maier 2001; Cadenas and Cadenas 2002; Closa and Folch-Puy 2004; Crimi et al. 2006a, b; Goode and Webster 1993; Gutteridge and Mitchell 1999; Horn 1998; Javadi et al. 2005; Lagan et al. 2008; Lemineur et al. 2006; Mishra 2007; Protti and Singer 2006; Quinlan et al. 2001; Redl et al. 1993; Victor et al. 2004, 2005; Vlessis et al. 1995), and (local and circulating) free iron is raised in sepsis and related conditions (Duvigneau et al. 2008; Galley et al. 1996, 1997; Galley and Webster 1996; Ghio et al. 2003; Lagan et al. 2008), as is the iron siderophore-binding protein lipocalin-2 (Hattori et al. 2009).
lipocalin-2 Binding (binding) of in Horn associated with sepsis and cytokine
9) Confidence 0.03 Published 2010 Journal Arch Toxicol Section Body Doc Link PMC2988997 Disease Relevance 0.36 Pain Relevance 0.04
We prospectively enrolled liver transplant patients at our institutions to evaluate neutrophil gelatinase-associated lipocalin (NGAL), a marker of early renal injury, as a surrogate for AKI in patients undergoing liver transplantation.
lipocalin Binding (associated) of in liver associated with injury
10) Confidence 0.02 Published 2009 Journal Liver Transpl. Section Abstract Doc Link 19938135 Disease Relevance 0.80 Pain Relevance 0.08

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