INT16460

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 13.86
Pain Relevance 8.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PPBP) extracellular region (PPBP)
Anatomy Link Frequency
plasma 7
platelet 4
blood 2
coronary sinus 2
endothelial cell 1
PPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
aspirin 27 99.98 Very High Very High Very High
depression 20 99.98 Very High Very High Very High
Migraine 19 99.80 Very High Very High Very High
agonist 5 99.34 Very High Very High Very High
gABA 16 99.08 Very High Very High Very High
adenocard 4 98.88 Very High Very High Very High
Angina 42 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 20 99.98 Very High Very High Very High
Hemorrhage 6 99.86 Very High Very High Very High
Migraine With Aura 6 99.80 Very High Very High Very High
Acute Coronary Syndrome 100 99.68 Very High Very High Very High
Cv General 3 Under Development 34 98.80 Very High Very High Very High
Adhesions 10 98.72 Very High Very High Very High
Myocardial Infarction 29 97.16 Very High Very High Very High
Disease 13 96.96 Very High Very High Very High
Thrombocytosis 6 96.68 Very High Very High Very High
Atherosclerosis 2 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of aspirin to the patients affected by common and classic migraine caused a decrease in plasma beta-TG and PF4 concentration.
Negative_regulation (decrease) of beta-TG in plasma associated with aspirin, migraine with aura and migraine
1) Confidence 0.57 Published 1984 Journal Stroke Section Abstract Doc Link 6230778 Disease Relevance 0.79 Pain Relevance 1.08
Administration of aspirin (ASA) was more effective than flunarizine in inducing a decrease in beta-TG and PF4 plasma levels in migraineurs.
Negative_regulation (decrease) of beta-TG in plasma associated with aspirin
2) Confidence 0.57 Published 1985 Journal Cephalalgia Section Abstract Doc Link 3160472 Disease Relevance 0.89 Pain Relevance 0.89
The results showed decreases of plasma beta-thromboglobulin and platelet factor 4 levels (p less than 0.001) and platelet aggregation induced by epinephrine plus serotonin (p less than 0.001), whereas ADP-induced aggregation remained unchanged 30 min and 3 h after ketanserin administration.
Negative_regulation (decreases) of beta-thromboglobulin in plasma associated with serotonin
3) Confidence 0.50 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2412053 Disease Relevance 0.33 Pain Relevance 0.22
Ticlopidine also inhibits the release reaction of platelets, prolongs bleeding time, reduces plasma levels of platelet factor 4 and beta-thromboglobulin in patients in whom these proteins are elevated, and may also inhibit platelet adhesion, increase red cell filtrability and decrease whole blood viscosity.
Negative_regulation (reduces) of beta-thromboglobulin in blood associated with hemorrhage and adhesions
4) Confidence 0.43 Published 1987 Journal Drugs Section Abstract Doc Link 3304967 Disease Relevance 0.65 Pain Relevance 0.09
Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal.
Negative_regulation (reduction) of beta-TG in platelet associated with aspirin, thrombocytosis and erythermalgia
5) Confidence 0.42 Published 2003 Journal Pathol. Biol. Section Abstract Doc Link 12781799 Disease Relevance 1.42 Pain Relevance 0.30
There was a substantial increase in thromboxane B2 activity and a less significant elevation of PG F1 alpha, as well as a rise of TF IV and beta-TG.
Negative_regulation (rise) of beta-TG
6) Confidence 0.42 Published 1991 Journal Kardiologiia Section Abstract Doc Link 2046245 Disease Relevance 0.36 Pain Relevance 0.19
However, the beta-TG level was suppressed, decreasing from 119 +/- 14 to 99 +/- 19 ng/ml in the arterial blood (p less than 0.1) and from 114 +/- 9 to 103 +/- 17 ng/ml (p less than 0.1) in the coronary sinus blood.
Negative_regulation (decreasing) of beta-TG in coronary sinus
7) Confidence 0.42 Published 1991 Journal Jpn Heart J Section Abstract Doc Link 1833567 Disease Relevance 0.37 Pain Relevance 0.24
However, the beta-TG level was suppressed, decreasing from 119 +/- 14 to 99 +/- 19 ng/ml in the arterial blood (p less than 0.1) and from 114 +/- 9 to 103 +/- 17 ng/ml (p less than 0.1) in the coronary sinus blood.
Negative_regulation (suppressed) of beta-TG in coronary sinus
8) Confidence 0.42 Published 1991 Journal Jpn Heart J Section Abstract Doc Link 1833567 Disease Relevance 0.37 Pain Relevance 0.24
Migraineurs NO3- and ET-1 plasma levels, compared to control values, showed a significant decrease and increase respectively; fibrinogen, beta-TG and D-dimer appeared slightly lowered in migraineurs, while Htc remained in the normal limits; tPA, PAI-1 and FI were significantly reduced, while fibrinopeptide A, blood viscosity and plasma viscosity at a low shear rate (shr) exhibited a significant rise.
Spec (appeared) Negative_regulation (lowered) of beta-TG in plasma
9) Confidence 0.41 Published 1996 Journal Artery Section Abstract Doc Link 8864251 Disease Relevance 0.17 Pain Relevance 0.24
Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave.
Negative_regulation (decrease) of beta-thromboglobulin in plasma
10) Confidence 0.27 Published 1994 Journal Angiology Section Abstract Doc Link 8129189 Disease Relevance 0.60 Pain Relevance 0.09
As observed above, ICAM-1, IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors.
Negative_regulation (reduced) of NAP-2
11) Confidence 0.26 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.42 Pain Relevance 0.41
Administration of gallopamil (50 mg kg-1 three times a day for 30 days) reduced plasma levels of catecholamines, beta-thromboglobulin and TxB2 blood concentrations either under basal conditions or after CPT.
Negative_regulation (reduced) of beta-thromboglobulin in plasma associated with catecholamine
12) Confidence 0.17 Published 1995 Journal Pharmacol. Res. Section Abstract Doc Link 8668647 Disease Relevance 0.42 Pain Relevance 0.49
However, while aspirin lowered plasma NAP-2, statin treatment stimulated NAP-2 production in patients, peripheral blood mononuclear cells, and platelets.
Negative_regulation (lowered) of NAP-2 in platelets associated with aspirin
13) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0.37 Pain Relevance 0.36
Ticlopidine and aspirin/dipyridamole, but not xanthinol nicotinate, improved platelet aggregation, reduced beta-thromboglobulin, platelet factor IV and fibrinopeptide A concentrations, and increased antithrombin III concentrations and red blood cell filterability.
Negative_regulation (reduced) of beta-thromboglobulin in red blood cell associated with aspirin
14) Confidence 0.08 Published 1990 Journal J. Int. Med. Res. Section Abstract Doc Link 2147914 Disease Relevance 0.16 Pain Relevance 0.29
However, platelet factor IV increased consistently after invasive procedures, accounting for 104 of the total of 110 increases due to platelet activation in vivo as reflected by persistence of elevated levels of beta-thromboglobulin.
Negative_regulation (persistence) of beta-thromboglobulin in platelet
15) Confidence 0.07 Published 1984 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 6237142 Disease Relevance 1.09 Pain Relevance 0.17
Levels of fibrinopeptide A, beta-thromboglobulin, platelet factor 4, thromboxane B2 and the platelet aggregates ratio in blood were similar between the 2 groups before, during and after PGI2 infusion.
Negative_regulation (Levels) of beta-thromboglobulin in blood
16) Confidence 0.06 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 2109927 Disease Relevance 0.49 Pain Relevance 0.40
However, while aspirin lowered plasma NAP-2, statin treatment stimulated NAP-2 production in patients, peripheral blood mononuclear cells, and platelets.
Negative_regulation (lowered) of NAP-2 in mononuclear cells associated with aspirin
17) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0.37 Pain Relevance 0.36
Surprisingly, patients with ACS and depression exhibited the highest levels of platelet factor 4, beta-thromboglobulin, and platelet/endothelial cell adhesion molecule-1 when compared with myocardial infarction or angina patients without clinical depression.
Negative_regulation (exhibited) of beta-thromboglobulin in endothelial cell associated with acute coronary syndrome, angina, depression, myocardial infarction and adhesions
18) Confidence 0.03 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12960610 Disease Relevance 1.89 Pain Relevance 0.42
The in vitro platelet reactivity to ADP was determined at rest and the plasma levels of beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured before and immediately after exercise.
Negative_regulation (measured) of beta-thromboglobulin in plasma
19) Confidence 0.03 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 2949974 Disease Relevance 0.25 Pain Relevance 0.38
TGB is a selective competitive inhibitor of GAT1 that prevents GABA uptake.
Negative_regulation (inhibitor) of TGB associated with gaba
20) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.57 Pain Relevance 0.20

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