INT16461

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Context Info
Confidence 0.24
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.39
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
plaques 2
platelet 2
lung 2
T cells 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 99.98 Very High Very High Very High
lidocaine 9 99.86 Very High Very High Very High
Kappa opioid receptor 2 99.36 Very High Very High Very High
Inflammation 58 99.12 Very High Very High Very High
Angina 7 92.72 High High
cytokine 15 81.56 Quite High
adenocard 1 81.16 Quite High
metalloproteinase 1 80.08 Quite High
Inflammatory response 10 78.00 Quite High
opioid receptor 1 76.84 Quite High
Disease Link Frequency Relevance Heat
Infection 1 100.00 Very High Very High Very High
Atherosclerotic Plaque 3 99.74 Very High Very High Very High
INFLAMMATION 68 99.12 Very High Very High Very High
Hemorrhage 3 99.04 Very High Very High Very High
Lung Injury 22 99.00 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.12 Very High Very High Very High
Coronary Artery Disease 8 97.92 Very High Very High Very High
Pneumonia 66 97.24 Very High Very High Very High
Atherosclerosis 3 97.12 Very High Very High Very High
Cv General 3 Under Development 4 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus trapidil, a new antianginal agent appears to inhibit the production of platelet derived growth factors and may, therefore, protect the arteries from atherosclerosis as it promotes beneficial systemic hemodynamics in patients with depressed ventricular function.
Negative_regulation (inhibit) of Gene_expression (production) of factors in platelet associated with increased venous pressure under development
1) Confidence 0.24 Published 1991 Journal Jpn Heart J Section Abstract Doc Link 1833567 Disease Relevance 0.44 Pain Relevance 0.18
A decreased PC level was observed in 92% of cases and in 44% of controls (P = 0.008).
Negative_regulation (decreased) of Gene_expression (level) of PC
2) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.24 Pain Relevance 0
The apparent mechanism for the decreasing APC/PC ratio during hospitalization was a gradual improvement of PC levels without a concomitant increase in APC values (Figure 3a–c).
Negative_regulation (improvement) of Gene_expression (levels) of PC
3) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.30 Pain Relevance 0
PC was technically successful in all patients (success rate: 100%), with 4 complications (rate: 9.1%; one case of PC site infection and 3 cases of PC site bleeding).
Negative_regulation (case) of Gene_expression (infection) of PC associated with hemorrhage and infection
4) Confidence 0.17 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880266 Disease Relevance 0.75 Pain Relevance 0.09
Taken together, we have demonstrated a dual inhibitory function of lidocaine which inhibits PC biosynthesis in addition to its ability to block choline uptake profoundly in U937 cells.
Negative_regulation (inhibits) of Gene_expression (biosynthesis) of PC associated with lidocaine
5) Confidence 0.15 Published 1994 Journal Cell Biochem. Funct. Section Abstract Doc Link 8044894 Disease Relevance 0 Pain Relevance 0.37
At 2% halothane concentration, the observed decreases in PC synthesis were 12, 24, 31 and 34% for 2, 4, 8, and 12 h exposure, respectively.
Negative_regulation (decreases) of Gene_expression (synthesis) of PC
6) Confidence 0.08 Published 1994 Journal Anesthesiology Section Body Doc Link 8092514 Disease Relevance 0 Pain Relevance 0
RESULTS: During a 4-h exposure, PC synthesis was reduced by 10, 24, 29 and 36% for 1, 2, 4, and 8% halothane respectively when compared with control values.
Negative_regulation (reduced) of Gene_expression (synthesis) of PC
7) Confidence 0.08 Published 1994 Journal Anesthesiology Section Body Doc Link 8092514 Disease Relevance 0 Pain Relevance 0
The levels of alveolar coagulation biomarkers are majored by rhAPC administration in P.aeruginosa-induced lung injury
Negative_regulation (majored) of Gene_expression (administration) of rhAPC in lung associated with lung injury
8) Confidence 0.07 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 1.32 Pain Relevance 0.13
At T0 and thus ~12 h after intubation, severe and highly significant alterations to the surfactant system were encountered, with a ten-fold reduced phospholipid-to-protein ratio (Table 2), a large reduction in the relative amount of large surfactant aggregates (LA, Figure 1), a pronounced disturbance to the phospholipid and PC molecular species profile (Table 2) and a significant loss of all surfactant proteins (Table 2).
Negative_regulation (reduced) of Gene_expression (profile) of PC
9) Confidence 0.07 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0
At T0 and thus ~12 h after intubation, severe and highly significant alterations to the surfactant system were encountered, with a ten-fold reduced phospholipid-to-protein ratio (Table 2), a large reduction in the relative amount of large surfactant aggregates (LA, Figure 1), a pronounced disturbance to the phospholipid and PC molecular species profile (Table 2) and a significant loss of all surfactant proteins (Table 2).
Negative_regulation (reduction) of Gene_expression (profile) of PC
10) Confidence 0.07 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0
In conclusion, preeclamptic women have more pronounced deficiencies of PC, PS, ATIII and more APC resistance compared to normal pregnant women.
Negative_regulation (deficiencies) of Gene_expression (resistance) of PC
11) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.17 Pain Relevance 0
Local inflammation of the atherosclerotic plaques induces the expression of a number of growth factors and other potent molecules that contribute to vascular remodeling.
Negative_regulation (number) of Gene_expression (expression) of factors in plaques associated with atherosclerotic plaque and inflammation
12) Confidence 0.00 Published 2001 Journal Herz Section Abstract Doc Link 11349622 Disease Relevance 1.17 Pain Relevance 0.38
Micro-opioids inhibited synthesis of common transcription factors AP-1, c-fos, NF-kappaB, and nuclear factor of activated T cells in activated or stimulated immune cells, whereas micro-opioids activated NF-kappaB, GATA-3, and Kruppel-like factor 7 transcription factors in non-stimulated immune cells.
Negative_regulation (inhibited) of Gene_expression (synthesis) of factors in T cells associated with opioid
13) Confidence 0.00 Published 2006 Journal Neuroimmunomodulation Section Abstract Doc Link 16612131 Disease Relevance 0 Pain Relevance 1.02

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