INT164625

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLCO2B1, ABCC1) transmembrane transport (SLCO2B1, ABCC1) transport (ABCC1)
small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1) nucleolus (ABCC1)
Anatomy Link Frequency
skeletal muscle 2
SLCO2B1 (Homo sapiens)
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 91.56 High High
Pain 4 5.00 Very Low Very Low Very Low
Muscle Disease 4 5.00 Very Low Very Low Very Low
Rhabdomyolysis 2 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
OATP2B1 Positive_regulation (multidrug) of MRP in skeletal muscle
1) Confidence 0.52 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
OATP2B1 Positive_regulation (multidrug) of resistance-associated protein in skeletal muscle
2) Confidence 0.46 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0

General Comments

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