INT164627

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.95
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
skeletal muscle myoblast 4
synovial cells 2
brain 2
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 99.44 Very High Very High Very High
Bile 9 92.36 High High
Pain 7 76.08 Quite High
rheumatoid arthritis 17 74.64 Quite High
Inflammation 74 74.32 Quite High
Locus ceruleus 1 67.76 Quite High
Dopamine 1 56.52 Quite High
Catecholamine 5 51.80 Quite High
cytokine 27 27.68 Quite Low
COX-2 inhibitor 13 19.60 Low Low
Disease Link Frequency Relevance Heat
Adhesions 39 99.96 Very High Very High Very High
Apoptosis 68 98.96 Very High Very High Very High
Brain Injury 72 98.08 Very High Very High Very High
Disorder Of Lipid Metabolism 37 97.28 Very High Very High Very High
Carcinoma 3 96.24 Very High Very High Very High
Infection 4 94.52 High High
Renal Cancer 39 82.80 Quite High
Obesity 66 80.00 Quite High
Pheochromocytoma 8 78.40 Quite High
Pain 9 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this release is not linked to the transcriptional regulation of the ABCA1 gene, because apoA-I induced efflux does not lead to an increase in ABCA1 gene expression (figure 1).
Positive_regulation (increase) of Gene_expression (expression) of ABCA1 gene
1) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.35 Pain Relevance 0
NS398-induced reductions in 27-hydroxylase and ABCA1 message were observed as early as 3 hours and maintained through 72 hours (data not shown).
Positive_regulation (reductions) of Gene_expression (message) of ABCA1
2) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
Expression of Abca1 is upregulated by PPAR?
Positive_regulation (by) of Gene_expression (Expression) of Abca1
3) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.25 Pain Relevance 0.18
Statistical analyses of grading for cell surface DPP IV (DPP IV/CD26) and staging for both soluble and membrane-bound DPP IV activities were not significant.
Positive_regulation (staging) of Gene_expression (activities) of membrane-bound
4) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.37 Pain Relevance 0
Along with increased expression of membrane-bound adhesion molecules, our analysis revealed that brain trauma caused elevated circulating levels of sE-selectin (sCD62E), sICAM-1 (sCD54) and sVCAM-1 (sCD106), but lower sL-selectin levels.
Positive_regulation (increased) of Gene_expression (expression) of membrane-bound in brain associated with brain injury and adhesions
5) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.26 Pain Relevance 0.06
In the group given Doxazocin, there was a significant increase in serum progesterone and ovarian renin angiotensin system soluble and membrane-bound enzymes confirming that alpha adrenergic receptors caused inhibition of progesterone release.
Positive_regulation (increase) of Gene_expression (enzymes) of membrane-bound
6) Confidence 0.03 Published 2008 Journal Cases J Section Body Doc Link PMC2481240 Disease Relevance 0.22 Pain Relevance 0.09
In an in vitro model of differentiated, primary human skeletal muscle myoblast cells, we demonstrate basal membrane expression and drug efflux activity of MRP1, which contributes to reducing intracellular statin accumulation.
Positive_regulation (basal) of Gene_expression (expression) of membrane in skeletal muscle myoblast
7) Confidence 0.03 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
In an in vitro model of differentiated, primary human skeletal muscle myoblast cells, we demonstrate basal membrane expression and drug efflux activity of MRP1, which contributes to reducing intracellular statin accumulation.
Positive_regulation (demonstrate) of Gene_expression (expression) of membrane in skeletal muscle myoblast
8) Confidence 0.03 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
More recently, we demonstrated that adenoviral mediated gene transfer of membrane bound human TRAIL [12] induced apoptosis of both rabbit and human synovial cells in culture, albeit only at a high multiplicity of adenoviral infection.
Positive_regulation (mediated) of Gene_expression (transfer) of membrane bound in synovial cells associated with apoptosis and infection
9) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.35 Pain Relevance 0.34

General Comments

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