INT164629

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLCO2B1) transmembrane transport (SLCO2B1)
Anatomy Link Frequency
skeletal muscle myoblast 1
skeletal muscle 1
SLCO2B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 91.56 High High
Pain 4 5.00 Very Low Very Low Very Low
Muscle Disease 4 5.00 Very Low Very Low Very Low
Rhabdomyolysis 2 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we show that expression of human OATP2B1 in human skeletal muscle myoblast cells by adenoviral vectors increases intracellular accumulation and toxicity of statins and such effects were abrogated when cells overexpressed MRP1.
Gene_expression (expression) of OATP2B1 in skeletal muscle myoblast
1) Confidence 0.73 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.07 Pain Relevance 0
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
Gene_expression (expressed) of OATP2B1 in skeletal muscle
2) Confidence 0.56 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox