INT16463

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 6.28
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FTH1) mitochondrion (FTH1) oxidoreductase activity (FTH1)
transmembrane transport (FTH1)
Anatomy Link Frequency
canal 2
finger 2
blood 2
spleen 1
epithelial cells 1
FTH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatica 6 96.72 Very High Very High Very High
backache 37 95.40 Very High Very High Very High
cINOD 14 84.56 Quite High
Pain 62 77.08 Quite High
antagonist 5 75.20 Quite High
halothane 1 70.40 Quite High
isoflurane 2 69.28 Quite High
cva 1 68.08 Quite High
aspirin 4 62.36 Quite High
epidural 2 61.44 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 12 99.48 Very High Very High Very High
Mesothelioma 110 98.90 Very High Very High Very High
Pressure And Volume Under Development 2 98.84 Very High Very High Very High
Disease 24 98.68 Very High Very High Very High
Low Back Pain 59 98.40 Very High Very High Very High
Aging 7 97.04 Very High Very High Very High
Nerve Root Compression 9 96.72 Very High Very High Very High
Apoptosis 43 96.48 Very High Very High Very High
Pressure Volume 2 Under Development 21 92.60 High High
Lung Cancer 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Her symptoms were successfully improved after posterior lumbar interbody fusion (PLIF) at L5-S1; however, notable swelling in her left leg suddenly developed 2 days postoperatively.
Gene_expression (improved) of PLIF in posterior associated with pressure and volume under development
1) Confidence 0.65 Published 2007 Journal Journal of neurosurgery. Spine Section Abstract Doc Link 17233290 Disease Relevance 0.57 Pain Relevance 0.13
METHODS: This was a retrospective chart review of patients referred to a tertiary spine institute with complications after surgery where BMP-2 had been used in an off-label PLIF or TLIF application.
Gene_expression (application) of PLIF in spine
2) Confidence 0.65 Published 2008 Journal Spine J Section Body Doc Link 18037352 Disease Relevance 0 Pain Relevance 0
Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2).
Gene_expression (use) of PLIF in canal
3) Confidence 0.65 Published 2008 Journal Spine J Section Title Doc Link 18037352 Disease Relevance 0.08 Pain Relevance 0.08
CONCLUSIONS: It does appear that ectopic bone in the spinal canal associated with BMP-2 use in PLIF or TLIF may contribute to symptomatic neurologic findings in rare cases.
Gene_expression (use) of PLIF in canal
4) Confidence 0.65 Published 2008 Journal Spine J Section Body Doc Link 18037352 Disease Relevance 0 Pain Relevance 0
The cases of 12 patients who presented with failed PLIF were reviewed.
Gene_expression (presented) of PLIF
5) Confidence 0.58 Published 1991 Journal Spine Section Abstract Doc Link 1833832 Disease Relevance 0.20 Pain Relevance 0.14
Expression of S100P as well as FTH1 (Ferritin H), an iron-binding protein, whose transcript was also upregulated by black cohosh, is associated to immortalization and transformation of breast epithelial cells [60].


Gene_expression (Expression) of Ferritin H in epithelial cells
6) Confidence 0.41 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.65 Pain Relevance 0.04
This result was reproduced with two lots of horse-spleen apoferritin and upon repeated testing.
Gene_expression (reproduced) of apoferritin in spleen
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746312 Disease Relevance 0 Pain Relevance 0.03
Thus these retinoids, which do not share receptor binding properties, repressed apoferritin H expression, in contrast to atRA which was inactive in this test.
Gene_expression (expression) of apoferritin H
8) Confidence 0.14 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0.25 Pain Relevance 0
Our experience in ALIF/PLIF versus TLIF14 in a retrospective study of 53 ALIF/PLIF patients and 111 TLIF patients with lumbar degenerative disc disease demonstrates that TLIF has a shorter operative time, lesser blood loss, shorter hospital stay, and lower complications rates (51% in ALIF/PLIF fusion; 28% in TLIF).
Gene_expression (experience) of PLIF in blood associated with pressure volume 2 under development and disease
9) Confidence 0.13 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2856390 Disease Relevance 0.76 Pain Relevance 0.20
Our experience in ALIF/PLIF versus TLIF14 in a retrospective study of 53 ALIF/PLIF patients and 111 TLIF patients with lumbar degenerative disc disease demonstrates that TLIF has a shorter operative time, lesser blood loss, shorter hospital stay, and lower complications rates (51% in ALIF/PLIF fusion; 28% in TLIF).
Gene_expression (/) of PLIF in blood associated with pressure volume 2 under development and disease
10) Confidence 0.13 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2856390 Disease Relevance 0.76 Pain Relevance 0.20
Lumbar degenerative spinal deformity: Surgical options of PLIF, TLIF and MI-TLIF

Degenerative disease of the lumbar spine is common in ageing populations.

Gene_expression (options) of PLIF in spinal associated with aging and disease
11) Confidence 0.13 Published 2010 Journal Indian Journal of Orthopaedics Section Title Doc Link PMC2856390 Disease Relevance 0.78 Pain Relevance 0.10
In the PLIF with cages group, 2, 26, and 10 segments were treated Yonsei Med J Vol. 46, No. 1, 2005 at the L3/4, L4/5, and L5/s1 level, respectively, including 5 cases of one-stage 2 level PLIF.
Gene_expression (level) of PLIF
12) Confidence 0.10 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823038 Disease Relevance 0.32 Pain Relevance 0.27
In the PLIF with cages group, 2, 26, and 10 segments were treated Yonsei Med J Vol. 46, No. 1, 2005 at the L3/4, L4/5, and L5/s1 level, respectively, including 5 cases of one-stage 2 level PLIF.
Gene_expression (level) of PLIF
13) Confidence 0.10 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823038 Disease Relevance 0.46 Pain Relevance 0.46
Aung et al. [84] found that when two mesothelioma cell lines were treated with asbestos, the cells that expressed higher levels of FHC had a smaller percentage increase in hydrogen peroxide generation and experienced less apoptosis as compared to cells that expressed lower levels.
Gene_expression (expressed) of FHC in FHC associated with mesothelioma and apoptosis
14) Confidence 0.06 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.55 Pain Relevance 0
VA binding sites in the protein structures were defined as the pockets with solvent exclusion and aliphatic character that exceeded minimum values observed in the VA binding sites of serum albumin, firefly luciferase, and apoferritin.
Gene_expression (sites) of apoferritin
15) Confidence 0.03 Published 2008 Journal Journal of chemical information and modeling Section Abstract Doc Link 18808106 Disease Relevance 0 Pain Relevance 0.07
Among the known genes differentially expressed in HT-29 cells after sulindac treatment were those encoding acetylglucosaminyltransferase, ferritin heavy chain, zinc finger protein 165, aldose reductase, carcinoembryonic antigen, aldoketoreductase, NF-kappaB-activating kinase, lysosome-associated protein, RhoE = 26 kDa GTPase homologue, NADH oxidoreductase, G/T mismatch bindingprotein, TM7SF3, ADP/ATP carrier-like protein and chromosome segregation protein.
Gene_expression (expressed) of ferritin heavy chain in finger
16) Confidence 0.03 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 11093808 Disease Relevance 0.45 Pain Relevance 0.47
Among the known genes differentially expressed in HT-29 cells after sulindac treatment were those encoding acetylglucosaminyltransferase, ferritin heavy chain, zinc finger protein 165, aldose reductase, carcinoembryonic antigen, aldoketoreductase, NF-kappaB-activating kinase, lysosome-associated protein, RhoE = 26 kDa GTPase homologue, NADH oxidoreductase, G/T mismatch bindingprotein, TM7SF3, ADP/ATP carrier-like protein and chromosome segregation protein.
Gene_expression (expressed) of ferritin heavy chain in finger
17) Confidence 0.03 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 11093808 Disease Relevance 0.45 Pain Relevance 0.47

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