INT164631

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.00
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGFL7) extracellular region (EGFL7)
Anatomy Link Frequency
coronary artery 2
skeletal muscle 2
EGFL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 92.96 High High
ischemia 44 33.16 Quite Low
imagery 93 23.04 Low Low
withdrawal 2 19.76 Low Low
Angina 51 15.84 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 4 100.00 Very High Very High Very High
Cardiovascular Disease 40 88.16 High High
Coronary Artery Disease 360 82.80 Quite High
Myocardial Infarction 59 75.92 Quite High
Disorder Of Lipid Metabolism 28 74.40 Quite High
Renal Insufficiency 3 71.48 Quite High
Hypertension 21 70.48 Quite High
Obesity 9 69.92 Quite High
Stroke 42 69.44 Quite High
Diabetes Mellitus 132 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results identify key membrane transporters as modulators of skeletal muscle statin exposure and toxicity.


Regulation (modulators) of Gene_expression (exposure) of statin in skeletal muscle
1) Confidence 0.08 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.06 Pain Relevance 0
By comparison, statin therapy attenuated changes in CAC scores averaging 13% (Table 3) [98, 126–128].Fig. 6Summary meta-analysis of randomized control trials (RCT) on the rffect of Statin therapy (Rx) on CAC progression
Regulation (attenuated) of Gene_expression (therapy) of statin
2) Confidence 0.06 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.28 Pain Relevance 0
Results of randomized clinical trials on effect of statin therapy on coronary artery calcium progression
Regulation (effect) of Gene_expression (therapy) of statin in coronary artery
3) Confidence 0.06 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.35 Pain Relevance 0
By comparison, statin therapy attenuated changes in CAC scores averaging 13% (Table 3) [98, 126–128].Fig. 6Summary meta-analysis of randomized control trials (RCT) on the rffect of Statin therapy (Rx) on CAC progression
Regulation (rffect) of Gene_expression (therapy) of Statin
4) Confidence 0.06 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.15 Pain Relevance 0
This was most likely due to more severe hypercholesterolemia in patients on a higher statin dose.57
Regulation (hypercholesterolemia) of Gene_expression (dose.57) of statin associated with hyperlipidemia
5) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.60 Pain Relevance 0.05
Another meta-analysis evaluated data on 51,351 patients from 18 randomized, placebo-controlled statin trials to determine efficacy of statin monotherapy in patients ?
Regulation (controlled) of Spec (determine) Gene_expression (trials) of statin
6) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.28 Pain Relevance 0
Another meta-analysis evaluated data on 51,351 patients from 18 randomized, placebo-controlled statin trials to determine efficacy of statin monotherapy in patients ?
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (trials) of statin
7) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.28 Pain Relevance 0

General Comments

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