INT164633

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 10.46
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGFL7) extracellular region (EGFL7)
Anatomy Link Frequency
coronary artery 1
endothelial cells 1
liver 1
skeletal muscle 1
platelets 1
EGFL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 280 99.98 Very High Very High Very High
aspirin 139 99.90 Very High Very High Very High
Inflammatory marker 36 98.56 Very High Very High Very High
Angina 115 97.92 Very High Very High Very High
Restless leg syndrome 62 97.40 Very High Very High Very High
Bile 5 96.20 Very High Very High Very High
Inflammatory response 8 94.80 High High
chemokine 45 91.88 High High
Potency 7 91.16 High High
cytokine 15 80.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 314 99.98 Very High Very High Very High
Hyperlipidemia 26 99.50 Very High Very High Very High
Coronary Artery Disease 596 99.20 Very High Very High Very High
Atherosclerosis 186 99.16 Very High Very High Very High
Acute Coronary Syndrome 216 98.88 Very High Very High Very High
Cv General 3 Under Development 86 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 126 97.40 Very High Very High Very High
Myocardial Infarction 210 94.72 High High
Hypertension 182 91.92 High High
Obesity 79 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that aspirin and statin use was significantly higher when the other therapy was present; however, the incremental use became progressively greater for statins over time.
Gene_expression (use) of statin associated with aspirin
1) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283363 Disease Relevance 0.21 Pain Relevance 0.55
The combination of amlodipine and atorvastatin tended to reduce atherosclerosis even more, possibly especially in modest statin responders, which may have implications for clinical practice.32 Mason and colleagues have observed that the combination of atorvastatin and amlodipine produces a synergistic reduction in oxidative damage to human LDL, an effect not observed with other combinations of amlodipine and statins.33
Gene_expression (responders) of statin associated with atherosclerosis
2) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686256 Disease Relevance 0.88 Pain Relevance 0.03
CONCLUSIONS: These results identify key membrane transporters as modulators of skeletal muscle statin exposure and toxicity.


Gene_expression (exposure) of statin in skeletal muscle
3) Confidence 0.11 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.05 Pain Relevance 0
Atorvastatin, a second-generation statin, was introduced in 1996 and reduces LDL-C by 41%–61% in hypercholesterolemic patients.


Gene_expression (generation) of statin
4) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686256 Disease Relevance 0.36 Pain Relevance 0.03
These patients were not on statin therapy which has been shown to reduce IL-6 and CRP production in the endothelial and liver cells [26,27].
Gene_expression (production) of statin in liver
5) Confidence 0.09 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.14 Pain Relevance 0.83
However, while aspirin lowered plasma NAP-2, statin treatment stimulated NAP-2 production in patients, peripheral blood mononuclear cells, and platelets.
Gene_expression (production) of statin in platelets associated with aspirin
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0.33 Pain Relevance 0.36
lower among those on statin therapy but not statistically different
Gene_expression (therapy) of statin
7) Confidence 0.08 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 0.58 Pain Relevance 0.15
By comparison, statin therapy attenuated changes in CAC scores averaging 13% (Table 3) [98, 126–128].Fig. 6Summary meta-analysis of randomized control trials (RCT) on the rffect of Statin therapy (Rx) on CAC progression
Gene_expression (therapy) of statin
8) Confidence 0.08 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.28 Pain Relevance 0
Results of randomized clinical trials on effect of statin therapy on coronary artery calcium progression
Gene_expression (therapy) of statin in coronary artery
9) Confidence 0.08 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.35 Pain Relevance 0
By comparison, statin therapy attenuated changes in CAC scores averaging 13% (Table 3) [98, 126–128].Fig. 6Summary meta-analysis of randomized control trials (RCT) on the rffect of Statin therapy (Rx) on CAC progression
Gene_expression (therapy) of Statin
10) Confidence 0.08 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.10 Pain Relevance 0
To validate ENA-78 as a statin target in inflammation typical of ACS, endothelial cells (HUVECs) were treated with IL-1?
Gene_expression (target) of statin in endothelial cells associated with acute coronary syndrome and inflammation
11) Confidence 0.08 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2518836 Disease Relevance 0.73 Pain Relevance 0.19
0.48), while patients with the C/C genotype prescribed statin therapy had a numerically greater, although not significant, mortality rate compared to those not prescribed statin therapy (35.3% versus 21.4%, respectively; p?
Gene_expression (therapy) of statin
12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0.08 Pain Relevance 0.04
0.48), while patients with the C/C genotype prescribed statin therapy had a numerically greater, although not significant, mortality rate compared to those not prescribed statin therapy (35.3% versus 21.4%, respectively; p?
Gene_expression (therapy) of statin
13) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0.12 Pain Relevance 0.04
on anti-inflammatory statin therapy demonstrated
Gene_expression (therapy) of statin associated with inflammation
14) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.57 Pain Relevance 0.23
This was most likely due to more severe hypercholesterolemia in patients on a higher statin dose.57
Gene_expression (dose.57) of statin associated with hyperlipidemia
15) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.54 Pain Relevance 0.05
Subjects living in a rural environment (HR 0.89; 0.85–0.94) were also less likely to cease their statin agents.
Gene_expression (agents) of statin
16) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.21 Pain Relevance 0.04
The findings did not differ for primary or secondary prevention.26,27 More recent meta-analysis of 14 statin (n = 100,827), 7 fibrates (n = 21,647), and 6 niacin (n = 4445) trials, and 1 trial each of a bile acid sequestrant (n = 3806), diet (n = 458), and ileal bypass surgery (n = 838) detected the same relationship.28
Gene_expression (analysis) of statin in bile associated with bile
17) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.50 Pain Relevance 0.14
The findings were consistent in statin and non-statin trials, suggesting that there was no additional pleiotropic effect from statin therapy beyond LDL cholesterol reduction.
Gene_expression (consistent) of statin
18) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.41 Pain Relevance 0.06
The authors speculated that physicians who wrote the most statin prescriptions were more likely to work in the primary care settings and therefore had less time to spend with patients, rather than specialists.60 Unfortunately, this study did not have data on specialty of physicians included in the study.
Gene_expression (prescriptions) of statin
19) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0 Pain Relevance 0
Although we have taken care to adjust for statin use in our analysis, we do not have information on the baseline lipid levels of these subjects to understand the proportion of cholesterol lowering effect that statins have on the circulating lipid levels.
Gene_expression (use) of statin
20) Confidence 0.05 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0 Pain Relevance 0

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