INT164656

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 6.51
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocytes 8
LS174T 6
macrophages 2
livers 2
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 1314 100.00 Very High Very High Very High
cytokine 134 99.96 Very High Very High Very High
agonist 11 97.44 Very High Very High Very High
Inflammatory mediators 3 91.76 High High
tricyclic antidepressant 1 91.68 High High
aspirin 54 89.12 High High
antagonist 26 88.96 High High
Inflammation 361 85.12 High High
cINOD 29 82.80 Quite High
dexamethasone 36 74.96 Quite High
Disease Link Frequency Relevance Heat
Repression 38 100.00 Very High Very High Very High
Cirrhosis 110 99.84 Very High Very High Very High
Colon Cancer 14 97.20 Very High Very High Very High
Fibrosis 8 96.68 Very High Very High Very High
Leukemia 52 95.92 Very High Very High Very High
Obesity 37 93.44 High High
Disease 167 92.72 High High
INFLAMMATION 422 91.76 High High
Rheumatoid Arthritis 202 87.28 High High
Myeloid Leukemia 28 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
decreased membrane expression of CD36 (46.5 ± 6.9 versus 82.9 ± 18.5, -44%, p = 0.04).
Negative_regulation (decreased) of Gene_expression (expression) of CD36
1) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.04
On the other hand, the administration of antioxidants, such as vitamin E, leads to a reduction in CD36 expression in murine peritoneal macrophages, and human endothelial cells, and macrophages derived from human monocytes [20,22,39].
Negative_regulation (reduction) of Gene_expression (expression) of CD36 in monocytes
2) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.12 Pain Relevance 0.24
, a TH1 cytokine, inhibits CD36 expression via reduction of PPAR?
Negative_regulation (inhibits) of Gene_expression (expression) of CD36 associated with cytokine
3) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.22 Pain Relevance 0.16
Since redox signaling is involved in the regulation of CD36 expression in human monocytes [21,22], we analyzed its role in the repression of CD36 membrane expression induced by TNF?
Negative_regulation (repression) of Gene_expression (expression) of CD36 in monocytes associated with repression
4) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.10 Pain Relevance 0
reduced membrane expression of CD36 in a dose-dependent manner: -9% (91.6 ± 10.3 versus 100.3 ± 10.9, p = 0.3), -29% (71.2 ± 13.1 versus 100.3 ± 10.9, p = 0.002) and -59% (41.4 ± 4.5 versus 100.3 ± 10.9, p = 0.003) for 0.1, 1 and 10 ng/ml TNF?
Negative_regulation (reduced) of Gene_expression (expression) of CD36
5) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.13
We here show that treatment of LS174T cells with indomethacin reduced arachidonic acid uptake as well as reduced expressions of fatty acid translocase/CD36 and peroxisome proliferators-activated receptor gamma.
Negative_regulation (reduced) of Gene_expression (expressions) of CD36 in LS174T
6) Confidence 0.57 Published 2010 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19944063 Disease Relevance 0.42 Pain Relevance 0.28
inhibits both CD36 membrane expression and mRNA expression.
Negative_regulation (inhibits) of Gene_expression (expression) of CD36
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.06 Pain Relevance 0.40
inhibits both CD36 membrane expression and mRNA expression in human monocytes.
Negative_regulation (inhibits) of Gene_expression (expression) of CD36 in monocytes
8) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.08 Pain Relevance 0.29
inhibits both CD36 membrane expression and mRNA expression.
Negative_regulation (inhibits) of Gene_expression (expression) of CD36
9) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906797 Disease Relevance 0.74 Pain Relevance 0.50
In contrast, the combination of adalimumab and DPI inhibited the effect of adalimumab on CD36 membrane expression, which returned to levels observed in basal conditions (108.3 ± 25.4 versus 88 ± 10.9, +23%, p = 0.07).
Negative_regulation (inhibited) of Gene_expression (expression) of CD36 associated with adalimumab
10) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.47
decreased CD36 expression (35.9 ± 7.8 versus 86.2 ± 6.8, -52%, p = 1 × 10-5) and this effect was not affected by Trolox® (42. 3 ± 4 versus 86.2 ± 6.8, -60%, p = 6 × 10-6).


Negative_regulation (decreased) of Gene_expression (expression) of CD36
11) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.07 Pain Relevance 0.16
inhibits both CD36 membrane expression and mRNA expression, an anti-TNF?
Negative_regulation (inhibits) of Gene_expression (expression) of CD36
12) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.87 Pain Relevance 0.33
We here show that treatment of LS174T cells with indomethacin reduced arachidonic acid uptake as well as reduced expressions of fatty acid translocase/CD36 and peroxisome proliferators-activated receptor gamma.
Negative_regulation (reduced) of Gene_expression (expressions) of CD36 in LS174T
13) Confidence 0.42 Published 2010 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19944063 Disease Relevance 0.42 Pain Relevance 0.28
, which induces ROS production, decreases CD36 expression and that this effect is not altered by antioxidant.
Negative_regulation (decreases) of Gene_expression (expression) of CD36
14) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.28 Pain Relevance 0.18
On the other hand, the administration of antioxidants, such as vitamin E, leads to a reduction in CD36 expression in murine peritoneal macrophages, and human endothelial cells, and macrophages derived from human monocytes [20,22,39].
Negative_regulation (reduction) of Gene_expression (expression) of CD36 in monocytes
15) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.12 Pain Relevance 0.24
-induced decrease of CD36 membrane expression (35.3 ± 15.5 versus 106.9 ± 11.3, p = 0.0004).
Negative_regulation (decrease) of Gene_expression (expression) of CD36
16) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.09
(10 ng/ml) reduced CD36 mRNA expression by 72% (mRNA relative level ± SD: 0.28 ± 0.05, p = 0.002), while adalimumab (1 ?
Negative_regulation (reduced) of Gene_expression (expression) of CD36 associated with adalimumab
17) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.32
Figure 4a shows that adalimumab increased CD36 membrane expression (233.7 ± 43.7 versus 122.8 ± 23.2, +70%, p = 0.02), while GW9662 did not significantly decrease CD36 membrane expression (93.8 ± 31.8 versus 122.8 ± 23.2, -24%, p = 0.2), in comparison to basal conditions.
Neg (not) Negative_regulation (decrease) of Gene_expression (expression) of CD36 associated with adalimumab
18) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.42
Next, we investigated whether the reduction of membrane expression of CD36 induced by TNF?
Spec (whether) Negative_regulation (reduction) of Gene_expression (expression) of CD36
19) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.22
THP-1 cells into macrophages, as shown by the expression of CD36 scavenger
Negative_regulation (shown) of Gene_expression (expression) of CD36 in macrophages
20) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.19 Pain Relevance 0.08

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