INT164669

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nucb2) endoplasmic reticulum (Nucb2) nucleus (Nucb2)
DNA binding (Nucb2) cytoplasm (Nucb2)
Anatomy Link Frequency
brain 2
adipocytes 1
Nucb2 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 2 90.88 High High
anesthesia 6 90.00 High High
Locus ceruleus 6 66.24 Quite High
Raphe 2 61.36 Quite High
medulla 8 55.20 Quite High
Bile 16 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 17 99.90 Very High Very High Very High
Targeted Disruption 38 98.98 Very High Very High Very High
Stress 9 97.40 Very High Very High Very High
Ileus 2 96.56 Very High Very High Very High
Hypertrophy 1 89.48 High High
Fatty Liver 5 70.20 Quite High
Toxocariasis 4 54.48 Quite High
Rickets 18 5.00 Very Low Very Low Very Low
Metabolic Disorder 9 5.00 Very Low Very Low Very Low
Calcification 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats.
Positive_regulation (activates) of nesfatin-1 in brain
1) Confidence 0.31 Published 2010 Journal Peptides Section Title Doc Link 19944727 Disease Relevance 0.23 Pain Relevance 0.39
Therefore, we investigated whether abdominal surgery activates nesfatin-1-immunoreactive (ir) neurons in the rat brain.
Spec (whether) Positive_regulation (activates) of nesfatin-1 in brain
2) Confidence 0.22 Published 2010 Journal Peptides Section Abstract Doc Link 19944727 Disease Relevance 0.23 Pain Relevance 0.45
In contrast, fasting Fgf21 knockout mice showed increased lipolysis in adipocytes and increased serum NEFA levels.
Positive_regulation (increased) of NEFA in adipocytes associated with targeted disruption and obesity
3) Confidence 0.07 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.21 Pain Relevance 0
The effects of high concentrations of NEFA on isolated islets and clonal pancreatic insulin-secreting cells are dependent on the structure (i.e. whether saturated or unsaturated) of the fatty acid and the period of exposure during cell culture.
Positive_regulation (concentrations) of NEFA
4) Confidence 0.05 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0

General Comments

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