INT164676

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NGF, Ngfr) cell differentiation (Ngfr) endosome (NGF)
nuclear envelope (Ngfr) Golgi apparatus (Ngfr) cytoplasm (Ngfr)
NGF (Homo sapiens)
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 84.40 Quite High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 3 90.16 High High
Diabetic Nephropathy 2 86.64 High High
Pain 1 84.40 Quite High
Nociception 1 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show by Surface Plasmon Resonance analysis that the R100 mutation selectively disrupts binding of hNGF to p75NTR receptor, to an extent which depends on the substituting residue at position 100, while the affinity of hNGFR100 mutants for TrkA receptor is not affected.
Negative_regulation (disrupts) of hNGF Binding (binding) of p75NTR receptor
1) Confidence 0.00 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19945432 Disease Relevance 0.50 Pain Relevance 0.08

General Comments

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