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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PKP1) cell adhesion (PKP1) nucleolus (PKP1)
plasma membrane (PKP1) nucleus (PKP1) signal transducer activity (PKP1)
PKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 68.40 Quite High
Disease Link Frequency Relevance Heat
Syndrome 2 75.00 Quite High
Ectodermal Dysplasia 2 75.00 Quite High
Congenital Anomalies 1 63.04 Quite High
Hypotrichosis 1 58.32 Quite High
Alopecia 1 56.96 Quite High
Hypohidrosis 1 56.16 Quite High
Acanthosis 1 25.00 Low Low
Acantholysis 1 25.00 Low Low
Epidermolysis Bullosa Simplex 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathogenic mutations have now been described in ten different desmosomal proteins: plakophilin 1 (PKP1) and 2 (PKP2); desmoplakin; plakoglobin; desmoglein 1, 2, and 4; desmocollin 2, and 3 corneodesmosin.
Negative_regulation (desmoplakin) of PKP1
1) Confidence 0.43 Published 2010 Journal Dermatol Clin Section Abstract Doc Link 19945625 Disease Relevance 0.38 Pain Relevance 0.07

General Comments

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