INT164682

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.04
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PKP1) cell adhesion (PKP1) nucleolus (PKP1)
plasma membrane (PKP1) nucleus (PKP1) signal transducer activity (PKP1)
Anatomy Link Frequency
skin 2
hepatocytes 1
lateral 1
plaque 1
heart 1
PKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 94.88 High High
Kinase C 52 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acantholysis 262 97.32 Very High Very High Very High
Acanthosis 2 96.76 Very High Very High Very High
Alopecia 10 96.44 Very High Very High Very High
Heart Defects 16 95.04 Very High Very High Very High
Epidermolysis Bullosa Simplex 2 93.64 High High
Syndrome 12 90.08 High High
Ectodermal Dysplasia 8 88.80 High High
Congenital Anomalies 2 84.40 Quite High
Death 4 82.12 Quite High
Disease 72 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of PKP1 expression results in an integral weakness within the desmosomal plaque, leading to desmosomal detachment and cell-cell separation.
Gene_expression (expression) of PKP1 in plaque
1) Confidence 0.78 Published 2010 Journal Dermatol Clin Section Abstract Doc Link 19945625 Disease Relevance 0.92 Pain Relevance 0.07
Loss of PKP1 expression in human skin leads to skin erosions and crusting, notably with perioral fissuring as well as palmoplantar hyperkeratosis with painful cracking of the skin.
Gene_expression (expression) of PKP1 in skin associated with pain
2) Confidence 0.78 Published 2010 Journal Dermatol Clin Section Abstract Doc Link 19945625 Disease Relevance 0.58 Pain Relevance 0.09
Because cardiomyocytes in contrast to epithelial cells express only plakophilin 2 but not plakophilin 1 and 3, defects were present in the heart only, whereas epithelia were not affected.
Gene_expression (express) of plakophilin 1 in heart
3) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.17 Pain Relevance 0
On the other hand, mutations in Dsg 1 and plakophilin 1, which are primarily expressed in the epidermis, cause skin defects whereas loss of Dsg 4 in hair follicles results in hair loss.
Gene_expression (expressed) of plakophilin 1 in skin associated with alopecia
4) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.14 Pain Relevance 0
Plakophilin 3 is present in most simple epithelia except hepatocytes as well as in stratified epithelia, whereas plakophilin 1 is restricted to stratified and complex epithelia.
Gene_expression (restricted) of plakophilin 1 in hepatocytes
5) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.14 Pain Relevance 0
On the other hand, because plakophilin 1 is located in the dense inner desmosomal plaque whereas cytokeratin filaments only loop into the outer plaque, it is believed that plakophilin 1 enhances desmoplakin lateral interactions but does not directly associate with cytokeratin filaments in vivo (Hatzfeld 2007; North et al. 1999).
Gene_expression (enhances) of plakophilin 1 in lateral
6) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.11 Pain Relevance 0

General Comments

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