INT164683

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PKP1) cell adhesion (PKP1) nucleolus (PKP1)
plasma membrane (PKP1) nucleus (PKP1) signal transducer activity (PKP1)
Anatomy Link Frequency
plaque 2
skin 2
PKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 94.88 High High
Disease Link Frequency Relevance Heat
Acantholysis 2 97.64 Very High Very High Very High
Acanthosis 2 97.08 Very High Very High Very High
Epidermolysis Bullosa Simplex 2 93.96 High High
Syndrome 4 90.40 High High
Ectodermal Dysplasia 4 89.12 High High
Congenital Anomalies 2 84.40 Quite High
Hypotrichosis 2 79.68 Quite High
Alopecia 2 78.32 Quite High
Hypohidrosis 2 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of PKP1 expression in human skin leads to skin erosions and crusting, notably with perioral fissuring as well as palmoplantar hyperkeratosis with painful cracking of the skin.
Negative_regulation (Loss) of Gene_expression (expression) of PKP1 in skin associated with pain
1) Confidence 0.59 Published 2010 Journal Dermatol Clin Section Abstract Doc Link 19945625 Disease Relevance 0.58 Pain Relevance 0.09
Loss of PKP1 expression results in an integral weakness within the desmosomal plaque, leading to desmosomal detachment and cell-cell separation.
Negative_regulation (Loss) of Gene_expression (expression) of PKP1 in plaque
2) Confidence 0.43 Published 2010 Journal Dermatol Clin Section Abstract Doc Link 19945625 Disease Relevance 0.92 Pain Relevance 0.07

General Comments

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