INT164696

Context Info Confidence 0.01 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 1.46 Pain Relevance 3.76

Anatomy Link Frequency respiratory 1 Depmq1 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 18 100.00 epidural 10 100.00 Patient controlled alalgesia 4 99.20 analgesia 4 98.52 Pain 6 98.04 Antiemetics 2 98.04 depression 4 97.44 Perioperative pain 2 96.72 antagonist 2 88.92 Opioid 2 84.12

Disease Link Frequency Relevance Heat Vomiting 8 99.60 Respiratory Failure 4 97.92 Post Operative Pain 2 96.72 Post-operative Nausea 6 96.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aprepitant vs. multimodal prophylaxis in the prevention of nausea and vomiting following extended-release epidural morphine.

Localization (release) of epidural morphine associated with vomiting, epidural, antiemetics and morphine

1) Confidence 0.01 Published 2010 Journal Pain Pract Section Title Doc Link 20230453 Disease Relevance 0.57 Pain Relevance 1.05

BACKGROUND: Extended-release epidural morphine (EREM) is an effective option for postoperative analgesia following major orthopedic surgery; however, postoperative nausea/vomiting (PONV) is a recognized limitation.

Localization (release) of epidural morphine associated with post-operative nausea, vomiting, epidural, analgesia and morphine

2) Confidence 0.01 Published 2010 Journal Pain Pract Section Abstract Doc Link 20230453 Disease Relevance 0.52 Pain Relevance 0.65

Meta-analysis of the effect of extended-release epidural morphine versus intravenous patient-controlled analgesia on respiratory depression.

Localization (release) of epidural morphine in respiratory associated with depression, respiratory failure, patient controlled alalgesia, epidural and morphine

3) Confidence 0.00 Published 2009 Journal J Opioid Manag Section Title Doc Link 19947071 Disease Relevance 0.19 Pain Relevance 1.07

OBJECTIVE: Extended-release epidural morphine (EREM) is a single-dose, extended-release epidural morphine formulation intended to provide postoperative pain relief over a 48-hour period.

Localization (release) of epidural morphine associated with epidural, perioperative pain and morphine

4) Confidence 0.00 Published 2009 Journal J Opioid Manag Section Abstract Doc Link 19947071 Disease Relevance 0.17 Pain Relevance 1.00

General Comments

This test has worked.