INT1647

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2011
Negated 5
Speculated 2
Reported most in Abstract
Documents 54
Total Number 56
Disease Relevance 13.44
Pain Relevance 8.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 20
plasma 4
arms 2
ovary 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 47 99.76 Very High Very High Very High
Endogenous opioid 14 99.66 Very High Very High Very High
Opioid 17 99.42 Very High Very High Very High
Clonidine 15 99.32 Very High Very High Very High
Morphine 4 99.04 Very High Very High Very High
opiate 14 99.00 Very High Very High Very High
antagonist 379 98.32 Very High Very High Very High
agonist 365 96.16 Very High Very High Very High
abdominal pain 4 94.72 High High
endometriosis 67 94.64 High High
Disease Link Frequency Relevance Heat
Adenoma 18 100.00 Very High Very High Very High
Obesity 112 99.80 Very High Very High Very High
Adrenal Cancer 11 99.56 Very High Very High Very High
Cancer 54 98.60 Very High Very High Very High
Polycystic Ovary Syndrome 107 98.16 Very High Very High Very High
Reprotox - General 1 244 97.92 Very High Very High Very High
Reprotox - General 3 359 97.32 Very High Very High Very High
Syndrome 14 96.68 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 120 94.80 High High
Thyroid Disease 14 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basal and stimulated LH levels were normal, whereas basal and stimulated FSH levels were totally suppressed.
Negative_regulation (suppressed) of FSH
1) Confidence 0.45 Published 2007 Journal Horm. Res. Section Body Doc Link 16974107 Disease Relevance 0.18 Pain Relevance 0
An inhibin B and estrogen-secreting adrenocortical carcinoma leading to selective FSH suppression.
Negative_regulation (suppression) of FSH associated with adrenal cancer
2) Confidence 0.45 Published 2007 Journal Horm. Res. Section Title Doc Link 16974107 Disease Relevance 0.39 Pain Relevance 0.14
Though the endogenous FSH was not fully suppressed in the present study, the estimation of elimination half-life of 46 hours in abdominal SC injection of the present study is similar to that of 37 hours in SC/IM [16,17], and 44 hours in IM [21] single 300 IU rhFSH injections.
Neg (not) Negative_regulation (suppressed) of FSH
3) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0.09
Future study with more subjects and with fully suppressed endogenous FSH may help to clarify those issues and provide even higher power in the analysis.


Negative_regulation (suppressed) of FSH
4) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
There are few shortcomings in the original design of this trial including (1) the small numbers of the subject enrolled which might result in less significant power in the statistical analysis; and (2) the endogenous FSH was not fully suppressed which made it difficult to provide a reliable pharmacokinetic analysis especially in the elimination half-life.
Neg (not) Negative_regulation (suppressed) of FSH
5) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0.03
The same 9 men also had decreases in basal serum FSH concentrations to within the normal range after surgery.
Negative_regulation (decreases) of FSH
6) Confidence 0.42 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6404924 Disease Relevance 0.84 Pain Relevance 0
Another man, who had a reduction in adenoma size and serum FSH concentration after surgery, subsequently had regrowth of the adenoma and concomitant resurgence of the FSH concentration.
Negative_regulation (reduction) of FSH associated with adenoma
7) Confidence 0.42 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6404924 Disease Relevance 0.90 Pain Relevance 0
Generally all test values are normal except that levels of estrogens, follicle stimulating hormone, and luteinizing hormone are usually reduced.
Neg (except) Negative_regulation (reduced) of follicle stimulating hormone in follicle
8) Confidence 0.42 Published 1984 Journal Acta Ginecol (Madr) Section Abstract Doc Link 12267262 Disease Relevance 1.28 Pain Relevance 0.11
By transfecting a Chinese hamster ovary cell line with FSH genes recombinant FSH could be stably produced and was introduced in clinical practice in 1992.9 Recombinant FSH is homogenous and free of contamination by proteins.
Negative_regulation (introduced) of FSH in ovary
9) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.17 Pain Relevance 0
In fertile subjects, dermorphin (5.5 micrograms/kg min for 30 min) decreases plasma LH (p less than 0.01 vs. baseline and placebo values), but not plasma FSH.
Negative_regulation (decreases) of FSH in plasma
10) Confidence 0.38 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.22
The results obtained point also to a possible different pattern of LH and FSH secretion after naloxone, that is after opiate receptor blockade.
Spec (possible) Negative_regulation (pattern) of FSH associated with narcan and opiate
11) Confidence 0.35 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.93
Addition of naloxone to CRH (5 women) reversed the LH and FSH inhibition when naloxone was started 1 h after the start of the CRH infusion.
Negative_regulation (inhibition) of FSH associated with narcan
12) Confidence 0.35 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.41
In in vitro fertilization (IVF) cycles, a low starting dose of follicle-stimulating hormone (FSH) and the use of 5000 iu human chorionic gonadotrophin (hCG) for final follicular maturation may benefit patients at high risk of OHSS.
Negative_regulation (dose) of follicle-stimulating hormone in follicle associated with ovarian hyperstimulation syndrome
13) Confidence 0.34 Published 2007 Journal Hum Fertil (Camb) Section Abstract Doc Link 17564886 Disease Relevance 0.86 Pain Relevance 0.04
In in vitro fertilization (IVF) cycles, a low starting dose of follicle-stimulating hormone (FSH) and the use of 5000 iu human chorionic gonadotrophin (hCG) for final follicular maturation may benefit patients at high risk of OHSS.
Negative_regulation (dose) of FSH in follicle associated with ovarian hyperstimulation syndrome
14) Confidence 0.34 Published 2007 Journal Hum Fertil (Camb) Section Abstract Doc Link 17564886 Disease Relevance 0.86 Pain Relevance 0.04
The unusual finding of selective FSH suppression suggested secretion of inhibin B by the adrenocortical tumor.
Negative_regulation (suppression) of FSH
15) Confidence 0.33 Published 2007 Journal Horm. Res. Section Body Doc Link 16974107 Disease Relevance 0.17 Pain Relevance 0
Blood was drawn prior and up to 180 min after drug administration for determination of GH, adrenocorticotropic hormone (ACTH), prolactin, thyrotropin (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), glucose, clonidine, and moxonidine concentrations.
Negative_regulation (determination) of follicle-stimulating hormone in follicle associated with clonidine
16) Confidence 0.29 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.71
CRH infusion induced a significant decrease in plasma LH and FSH levels in all women.
Negative_regulation (decrease) of FSH in plasma
17) Confidence 0.26 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.30
The mid-cycle serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) peaks were suppressed, but there were no differences between the pretreatment serum oestradiol values and those observed during the treatment cycles.
Negative_regulation (suppressed) of follicle-stimulating hormone in follicle
18) Confidence 0.25 Published 1988 Journal Maturitas Section Abstract Doc Link 2972897 Disease Relevance 0.24 Pain Relevance 0.05
Other measures have been tried by decreasing the FSH dose (step down protocol) to improve endometrial receptivity.
Negative_regulation (decreasing) of FSH
19) Confidence 0.23 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.07 Pain Relevance 0.04
Plasma levels of PRL, FSH and LH were unaffected by the drug.
Neg (unaffected) Negative_regulation (unaffected) of FSH in Plasma
20) Confidence 0.22 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2901180 Disease Relevance 0 Pain Relevance 0.22

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