INT164706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.28
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park7) mitochondrion organization (Park7) response to stress (Park7)
cytoplasm (Park7) cytosol (Park7) peptidase activity (Park7)
Park7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
pregabalin 10 99.72 Very High Very High Very High
Inflammation 12 91.36 High High
Pain 2 74.16 Quite High
Neuropathic pain 1 69.92 Quite High
Analgesic 1 68.48 Quite High
anticonvulsant 1 67.92 Quite High
fibrosis 20 48.56 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 52 100.00 Very High Very High Very High
Shock 5 96.88 Very High Very High Very High
INFLAMMATION 12 91.36 High High
Glioma 1 86.80 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 83.60 Quite High
Pain 2 74.16 Quite High
Neuropathic Pain 1 69.92 Quite High
Pulmonary Fibrosis 12 50.24 Quite High
Asthma 20 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DJ-1/PARK7, a negative regulator of the tumor suppressor PTEN and promoter of proliferative pathways and cell survival [53,54], was increased (>30-fold) at 24 hours.
Positive_regulation (increased) of DJ-1 associated with cancer
1) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.64 Pain Relevance 0.08
Drosophila protein J-1/Parkinson protein 7 (DJ-1/PARK7), a negative regulator of PTEN tumor suppressor and a potential prognostic marker for cancer, was increased by >30-fold at 24 hours and the tumor suppressor-related protein, hyaluronate binding protein-1 (HABP-1), was increased >15 fold (Fig. 4D and Table 1) while transgelin (TAGLN2), was the most significantly down-regulated protein at >14-fold (Fig. 4D and Table 2).
Positive_regulation (increased) of PARK7 associated with cancer
2) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.30 Pain Relevance 0
DJ-1/PARK7, a negative regulator of the tumor suppressor PTEN and promoter of proliferative pathways and cell survival [53,54], was increased (>30-fold) at 24 hours.
Positive_regulation (increased) of PARK7 associated with cancer
3) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.64 Pain Relevance 0.08
Drosophila protein J-1/Parkinson protein 7 (DJ-1/PARK7), a negative regulator of PTEN tumor suppressor and a potential prognostic marker for cancer, was increased by >30-fold at 24 hours and the tumor suppressor-related protein, hyaluronate binding protein-1 (HABP-1), was increased >15 fold (Fig. 4D and Table 1) while transgelin (TAGLN2), was the most significantly down-regulated protein at >14-fold (Fig. 4D and Table 2).
Positive_regulation (increased) of DJ-1 associated with cancer
4) Confidence 0.33 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.30 Pain Relevance 0
The calcium-ion-binding chaperone, calreticulin, and the oxidative response protein, DJ-1, were up-regulated after pregabalin treatment.
Positive_regulation (up-regulated) of DJ-1 associated with pregabalin
5) Confidence 0.18 Published 2010 Journal Cell Biol. Int. Section Abstract Doc Link 19947953 Disease Relevance 0.40 Pain Relevance 1.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox