INT164779

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pts) lyase activity (Pts) cellular_component (Pts)
cytoplasm (Pts)
Pts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 7 100.00 Very High Very High Very High
GCH1 4 99.46 Very High Very High Very High
Opioid 2 99.12 Very High Very High Very High
Bile 3 88.96 High High
Cancer pain 3 85.08 High High
cINOD 30 77.20 Quite High
Inflammation 2 75.32 Quite High
Pain 4 73.76 Quite High
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 98.40 Very High Very High Very High
Cancer Pain 3 85.08 High High
INFLAMMATION 5 75.32 Quite High
Pain 1 73.76 Quite High
Ulcers 20 58.92 Quite High
Enteropathy 4 26.80 Quite Low
Toxicity 3 5.00 Very Low Very Low Very Low
Stomach Ulcer 2 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In separate studies the inhibitor of inducible nitric oxide synthase, 2,4 diamino-6-hydroxy pyrimidine (DAHP; a potent inhibitor of tetrahydrobiopterin synthesis, which is a cofactor for the inducible nitric oxide synthase activity) 1.0 gm /kg b.w. was administered to 12 rats intra-peritonealy 1 hr before indomethacin (20 mg/kg) gavages.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of tetrahydrobiopterin associated with tetrahydrobiopterin
1) Confidence 0.01 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC103670 Disease Relevance 0.13 Pain Relevance 0.27
Thus, reduced GCH1 upregulation, here conferred by non-coding and non-splice site GCH1 variants known to lead to decreased tetrahydrobiopterin expression, delays the need for opioid therapy in cancer.
Negative_regulation (decreased) of Gene_expression (expression) of tetrahydrobiopterin associated with tetrahydrobiopterin, cancer, gch1 and opioid
2) Confidence 0.00 Published 2010 Journal Pain Section Abstract Doc Link 19959292 Disease Relevance 0.57 Pain Relevance 0.74

General Comments

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