INT164784

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 2.37
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
spinal cord 4
Il6 (Rattus norvegicus)
Cx3cr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 6 99.78 Very High Very High Very High
Spinal cord 10 99.68 Very High Very High Very High
Peripheral nerve injury 6 98.96 Very High Very High Very High
Eae 12 96.40 Very High Very High Very High
Thermal hyperalgesia 2 95.80 Very High Very High Very High
allodynia 2 94.80 High High
Pain 4 82.96 Quite High
Sciatic nerve 2 81.40 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.78 Very High Very High Very High
Nervous System Injury 8 98.52 Very High Very High Very High
Injury 12 96.40 Very High Very High Very High
Hyperalgesia 2 95.80 Very High Very High Very High
Pain 4 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest a new mechanism of neuropathic pain, in which IL-6 induces microglial CX3CR1 expression in the spinal cord through p38 MAPK activation, enhancing the responsiveness of microglia to fractalkine in the spinal cord, thus playing an important role in neuropathic pain after peripheral nerve injury.
IL-6 Positive_regulation (induces) of Gene_expression (expression) of CX3CR1 in spinal cord associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
1) Confidence 0.47 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 1.35 Pain Relevance 1.16
Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK.
Interleukin-6 Positive_regulation (induces) of Gene_expression (expression) of CX3CR1 in spinal cord associated with nervous system injury, peripheral nerve injury and spinal cord
2) Confidence 0.47 Published 2010 Journal Eur J Pain Section Title Doc Link 19959384 Disease Relevance 1.01 Pain Relevance 0.82

General Comments

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