INT1648

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2009
Negated 4
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 3.32
Pain Relevance 9.60

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signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
follicle 7
plasma 3
thyroid 2
blood 1
tendons 1
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 61 100.00 Very High Very High Very High
Clonidine 18 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
opiate 7 100.00 Very High Very High Very High
ketamine 6 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
anesthesia 2 100.00 Very High Very High Very High
Pain threshold 2 100.00 Very High Very High Very High
Opioid 18 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2 100.00 Very High Very High Very High
Cluster Headache 16 99.84 Very High Very High Very High
Reprotox - General 3 7 97.60 Very High Very High Very High
Trypanosomiasis 3 95.76 Very High Very High Very High
Parasitic Infection 1 95.00 High High
Thrombosis 2 91.96 High High
Endometriosis (extended) 1 91.44 High High
Hypotension 2 87.56 High High
Hypogonadotropic Hypogonadism 1 86.84 High High
Osteoarthritis 1 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings show that vasectomy does not produce any significant morphological alterations in the Leydig cells; this confirms the reports that both in man and rhesus monkeys no significant changes in the levels of testosterone or luteinizing hormone occur after vasectomy.
Neg (no) Regulation (changes) of luteinizing hormone in Leydig cells
1) Confidence 0.61 Published 1983 Journal Indian J. Med. Res. Section Abstract Doc Link 6874016 Disease Relevance 0 Pain Relevance 0.07
Opioid regulation of luteinizing hormone in amenorrheic patients after therapy for induction of ovulation.
Regulation (regulation) of luteinizing hormone associated with opioid
2) Confidence 0.52 Published 1987 Journal Fertil. Steril. Section Title Doc Link 3032691 Disease Relevance 0.33 Pain Relevance 0.42
It seems that LHB tenotomy was particularly effective for massive tears of two or more tendons.
Regulation (effective) of LHB in tendons
3) Confidence 0.44 Published 1999 Journal Arthroscopy Section Abstract Doc Link 10024034 Disease Relevance 0.16 Pain Relevance 0.15
In a controlled study, the effect of a new enkephalin analogue (FW 34-569, Sandoz) on respiratory function (ventilatory response to CO2), pain threshold (hot plate technique), and plasma cortisol, prolactin, growth hormone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was investigated in six normal subjects.
Spec (investigated) Regulation (effect) of luteinizing hormone in follicle associated with pain threshold and enkephalin
4) Confidence 0.18 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 6798813 Disease Relevance 0.17 Pain Relevance 0.59
The circadian changes in testosterone (T) and cortisol secretion and morning luteinizing hormone (LH) levels were evaluated in nine episodic cluster headache (CH) patients in active phase and in seven healthy volunteers, with collection of blood samples every 2 h for 24 h.
Regulation (changes) of luteinizing hormone in blood associated with cluster headache
5) Confidence 0.18 Published 1986 Journal Cephalalgia Section Abstract Doc Link 3698090 Disease Relevance 0.61 Pain Relevance 0.54
The purpose of this study was to evaluate the effects of dermorphin, a new synthetic powerful opiate-like heptapeptide, on plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in fertile and postmenopausal women.
Regulation (effects) of luteinizing hormone in plasma associated with opiate
6) Confidence 0.15 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.20
A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.
Regulation (effects) of luteinizing hormone in thyroid associated with narcan and clonidine
7) Confidence 0.13 Published 1979 Journal Neurosci. Lett. Section Title Doc Link 223091 Disease Relevance 0 Pain Relevance 0.91
Buprenorphine effects on plasma luteinizing hormone and prolactin in male heroin addicts.
Regulation (effects) of luteinizing hormone in plasma associated with buprenorphine
8) Confidence 0.12 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.05
Effect of naloxone treatment on luteinizing hormone and testosterone concentrations in boars with high and low libido.
Regulation (Effect) of luteinizing hormone associated with reprotox - general 3 and narcan
9) Confidence 0.04 Published 2009 Journal Reprod Biol Section Title Doc Link 19997477 Disease Relevance 0.62 Pain Relevance 0.43
Effect of delta-opioid receptor agonist deltorphin on circulating concentrations of luteinizing hormone and follicle stimulating hormone in healthy fertile women.
Regulation (Effect) of luteinizing hormone in follicle associated with narcan, agonist and opioid receptor
10) Confidence 0.04 Published 1998 Journal Hum. Reprod. Section Title Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.54
Maturational changes in opioidergic control of luteinizing hormone and follicle-stimulating hormone in ram lambs.
Regulation (control) of luteinizing hormone in follicle associated with narcan
11) Confidence 0.02 Published 1991 Journal J. Reprod. Fertil. Section Title Doc Link 1920278 Disease Relevance 0 Pain Relevance 0.43
Alosetron had no effect on serum concentrations of luteinizing hormone (LH) or follicle-stimulating hormone.
Neg (no) Regulation (effect) of luteinizing hormone in follicle
12) Confidence 0.02 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15387353 Disease Relevance 0.31 Pain Relevance 0.14
Modulation of luteinizing hormone and follicle-stimulating hormone in circulation by interactions between endogenous opioids and oestradiol during the peripubertal period of heifers.
Regulation (Modulation) of luteinizing hormone in follicle associated with narcan and endogenous opioid
13) Confidence 0.02 Published 1992 Journal J. Reprod. Fertil. Section Title Doc Link 1432947 Disease Relevance 0.07 Pain Relevance 0.56
Plasma luteinizing hormone levels in response to gonadotropin-releasing hormone agonist and clonidine in Trypanosoma congolense-infected female goats.
Regulation (response) of luteinizing hormone in Plasma associated with agonist and clonidine
14) Confidence 0.01 Published 1997 Journal Brain Res. Bull. Section Title Doc Link 9365802 Disease Relevance 0.28 Pain Relevance 0.43
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion prior to and during the gonadotrophin surge were not affected by naloxone (0.33 mg/kg body wt per h) administered from the time of medroxyprogesterone acetate withdrawal until 30 h after the onset of oestrus (n = 6).
Neg (not) Regulation (affected) of Luteinizing hormone in body associated with narcan and withdrawal
15) Confidence 0.01 Published 1991 Journal J. Reprod. Fertil. Section Abstract Doc Link 1909367 Disease Relevance 0 Pain Relevance 0.77
Total, free and carrier protein-bound testosterone levels were significantly diminished only in chronic CH, where luteinizing hormone (LH) peak values after intravenous administration of LHRH were also decreased.
Regulation (values) of luteinizing hormone associated with cluster headache
16) Confidence 0.01 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2663174 Disease Relevance 0.44 Pain Relevance 0.53
Using simulated short- and long-term effect studies, we evaluated the effect of ketamine anesthesia on serum cortisol, testosterone, and immunoreactive luteinizing hormone (ILH) and bioactive LH (BioLH) concentrations in adult male cynomolgus monkeys.
Regulation (effect) of immunoreactive luteinizing hormone associated with anesthesia and ketamine
17) Confidence 0.01 Published 1998 Journal Lab. Anim. Sci. Section Abstract Doc Link 10090027 Disease Relevance 0.07 Pain Relevance 0.25
Effect of clonidine on growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone in the serum of normal men.
Regulation (Effect) of luteinizing hormone in thyroid associated with clonidine
18) Confidence 0.01 Published 1975 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1184719 Disease Relevance 0.09 Pain Relevance 0.48
METHODS: We studied a group of 36 fertile women affected with moderate-to-severe cyclical mastalgia (mean age: 26.0 years) showing a normal menstrual history and normal basal levels of circulating hormones, including prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), testosterone (T), dehydroepiandrosterone sulphate (delta HEAs), androstenedione (A).
Regulation (affected) of luteinizing hormone in follicle
19) Confidence 0.01 Published 1997 Journal Minerva Med. Section Abstract Doc Link 9433398 Disease Relevance 0 Pain Relevance 0
Clonidine had no effect on serum prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyroid-stimulating hormone (TSH).
Neg (no) Regulation (effect) of luteinizing hormone in follicle associated with clonidine
20) Confidence 0.01 Published 1975 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1184719 Disease Relevance 0.08 Pain Relevance 0.47

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