INT1649

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Context Info
Confidence 0.46
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.65
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
skin 3
symphysis 1
syncytiotrophoblast 1
cytotrophoblast 1
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 12 99.84 Very High Very High Very High
Clonidine 6 99.76 Very High Very High Very High
opiate 22 99.68 Very High Very High Very High
narcan 18 99.64 Very High Very High Very High
Enkephalin 6 99.64 Very High Very High Very High
Analgesic 2 99.64 Very High Very High Very High
Morphine 10 99.12 Very High Very High Very High
adenocard 2 98.26 Very High Very High Very High
agonist 9 92.60 High High
Potency 2 89.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.96 Very High Very High Very High
Skin Cancer 4 99.90 Very High Very High Very High
Rheumatoid Arthritis 62 99.28 Very High Very High Very High
Cockayne Syndrome 220 98.78 Very High Very High Very High
Disease 16 84.44 Quite High
Syndrome 12 82.32 Quite High
Leukemia 2 76.48 Quite High
Bordatella Infection 4 73.60 Quite High
Hypertrophy 32 58.52 Quite High
Neurodegenerative Disease 4 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that kappa opioids stimulated the release of human placental lactogen (hPL) from trophoblastic cells and that this effect was prevented by co-incubation with naloxone.
Localization (release) of placental lactogen associated with narcan and opioid
1) Confidence 0.46 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.30
We previously reported that kappa opiates stimulated the release of human placental lactogen (hPL) from human placental cells.
Localization (release) of placental lactogen associated with opiate
2) Confidence 0.45 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.05 Pain Relevance 0.41
Adenosine 3':5'-cyclic monophosphate (cAMP) is not the mediator of kappa opiate effect on human placental lactogen release.
Localization (release) of placental lactogen associated with adenocard and opiate
3) Confidence 0.42 Published 1991 Journal Life Sci. Section Title Doc Link 1650874 Disease Relevance 0.07 Pain Relevance 0.65
In tennis players, the maximum CSA was located more distally in the non-dominant compared to the dominant side (12.6±8.5 vs. 22.9±1.2 cm from the pubic symphysis, respectively, P?
Localization (located) of CSA in symphysis
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013134 Disease Relevance 0.06 Pain Relevance 0
Also, Rankin et. al [19] found average CSA in both sides of RA (8.3 and 8.2 cm2, right and left sides, respectively) in subjects moderately active (involved 4 days a week in recreational sports) and slightly taller than our control group (+3 cm).
Localization (found) of CSA associated with rheumatoid arthritis
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013134 Disease Relevance 0.16 Pain Relevance 0.04
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Localization (release) of placental lactogen associated with analgesic and opioid
6) Confidence 0.37 Published 1993 Journal Mol. Cell. Endocrinol. Section Title Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.83
And third, mouse models with either a truncating mutation similar to a severe human CSB allele (CS1AN; K337STOP) [55] or a CSA knockout [56] manifest the characteristic UV sensitivity of CS, as well as an unexpected susceptibility to skin cancer not observed for human CSB and CSA mutations, but only a subtle developmental phenotype.
Localization (allele) of CS1AN in skin associated with targeted disruption, skin cancer and cockayne syndrome
7) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 1.04 Pain Relevance 0.07
This study was undertaken to examine the in vitro effect of morphine on hCG (human chorionic gonadotrophin) and hPL (human placental lactogen) release by 1st and 3rd trimester placental tissue explants.
Localization (release) of hPL associated with morphine
8) Confidence 0.34 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.69
Thus at 4–5 weeks EGF stimulates cytotrophoblast cell proliferation, whereas at 6–12 weeks it stimulates secretion of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) into the supernatant [19].
Localization (secretion) of placental lactogen in cytotrophoblast
9) Confidence 0.32 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.08 Pain Relevance 0
Within the placenta the syncytiotrophoblast also secretes human placental lactogen (hPL), which shares 67% sequence homology with prolactin and is able to signal through the prolactin receptor.
Localization (secretes) of placental lactogen in syncytiotrophoblast
10) Confidence 0.32 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0
Just as striking was the association of MER85 elements with genes that are repressed following UV irradiation (Tables S5 and S6); UV is known to cause nuclear translocation of CSA [75] which may in turn be required for full CSB function.
Localization (translocation) of CSA
11) Confidence 0.32 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.12 Pain Relevance 0.03
The clonidine effects on PL secretion are discussed in the frame of a possible adrenergic control of the release of this hormone.
Localization (secretion) of PL associated with clonidine
12) Confidence 0.30 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.91
And third, mouse models with either a truncating mutation similar to a severe human CSB allele (CS1AN; K337STOP) [55] or a CSA knockout [56] manifest the characteristic UV sensitivity of CS, as well as an unexpected susceptibility to skin cancer not observed for human CSB and CSA mutations, but only a subtle developmental phenotype.
Localization (allele) of CSA in skin associated with targeted disruption, skin cancer and cockayne syndrome
13) Confidence 0.30 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 1.05 Pain Relevance 0.07
This study was undertaken to examine the in vitro effect of morphine on hCG (human chorionic gonadotrophin) and hPL (human placental lactogen) release by 1st and 3rd trimester placental tissue explants.
Localization (release) of placental lactogen associated with morphine
14) Confidence 0.30 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.68
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
Localization (release) of chorionic gonadotropin hormone associated with opioid
15) Confidence 0.19 Published 1991 Journal Life Sci. Section Title Doc Link 1652048 Disease Relevance 0 Pain Relevance 0.99
And third, mouse models with either a truncating mutation similar to a severe human CSB allele (CS1AN; K337STOP) [55] or a CSA knockout [56] manifest the characteristic UV sensitivity of CS, as well as an unexpected susceptibility to skin cancer not observed for human CSB and CSA mutations, but only a subtle developmental phenotype.
Neg (not) Localization (observed) of CSA in skin associated with targeted disruption, skin cancer and cockayne syndrome
16) Confidence 0.15 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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