INT164902

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.20
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RL1, IL33) extracellular region (IL1RL1, IL33) signal transduction (IL1RL1)
plasma membrane (IL1RL1) intracellular (IL1RL1)
IL1RL1 (Homo sapiens)
IL33 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 100.00 Very High Very High Very High
Inflammatory response 2 99.92 Very High Very High Very High
Chronic pancreatitis 3 88.08 High High
Inflammation 25 76.28 Quite High
chemokine 6 70.76 Quite High
aspirin 5 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.56 Very High Very High Very High
Rhinitis 62 99.04 Very High Very High Very High
Asthma 17 95.08 Very High Very High Very High
Fibrosis 3 95.04 Very High Very High Very High
Eczema 31 91.44 High High
Nasal Polyps 6 67.12 Quite High
Chronic Sinusitis 14 66.28 Quite High
Anaphylaxis 1 53.84 Quite High
Pancreatitis 3 41.24 Quite Low
Eosinophilic Esophagitis 5 16.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: IL33 and its receptor complex (ST2L and IL1RAcP) constitute a novel signalling system which may play an important role in the pathogenesis of chronic pancreatitis.


ST2L Binding (complex) of IL33
1) Confidence 0.37 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP).
ST2L Binding (binds) of Interleukin 33 associated with cytokine
2) Confidence 0.36 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.10 Pain Relevance 0.18
OBJECTIVE: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP).
ST2L Binding (binds) of IL33 associated with cytokine
3) Confidence 0.36 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.10 Pain Relevance 0.18
IL1RL1 (ST2) was recently identified as the receptor for IL33 (a member of the IL1 family, although the IL33 gene is located on a separate chromosome).
IL1RL1 Binding (receptor) of IL33
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.01 Pain Relevance 0.18

General Comments

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