INT164915

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.25
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXCL2) extracellular region (CXCL2)
Anatomy Link Frequency
immune cells 1
MCF-7 1
CXCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 75 100.00 Very High Very High Very High
cytokine 21 100.00 Very High Very High Very High
Inflammation 112 93.04 High High
rheumatoid arthritis 49 92.08 High High
palliative 1 39.48 Quite Low
corticosteroid 13 36.56 Quite Low
Bioavailability 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 22 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 5 98.72 Very High Very High Very High
Polyps 29 98.56 Very High Very High Very High
Infection 2 98.28 Very High Very High Very High
Breast Cancer 104 97.68 Very High Very High Very High
Metastasis 12 96.92 Very High Very High Very High
Pulmonary Disease 73 95.80 Very High Very High Very High
Adenoma 36 93.76 High High
Disease 51 93.24 High High
INFLAMMATION 121 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, IL-8, CXCL1, CXCL2, CXCL3, and CCL20 had higher levels of expression in the polyps compared to normal, which is in keeping with the current study.
Gene_expression (had) of CXCL2 associated with polyps
1) Confidence 0.55 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.30 Pain Relevance 0.26
The disparity in angiogenic activity among CXC chemokine family members is attributed to three amino acid structural domains at the N terminus, Glu-Leu-Arg (ELR), which is present in angiogenic (i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8) [4-6], but not angiostatic (i.e., CXCL4, CXCL9, CXCL10, and CXCL11) CXC chemokines [7].
Gene_expression (present) of CXCL2 associated with chemokine
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.65 Pain Relevance 0.27
Arterial SMCs, in particular, express a large set of genes that mediate these interactions—such as cytokines/chemokines (IL6, CCL8, CCL7, CCL2, CXCL1, CXCL2, CXCL3, and CXCL6), complement pathway (complement factor B [CFB]), and surface receptor (ICAM1) (Figure 3B)—suggesting that vascular SMCs may themselves mediate recruitment of immune cells to the vascular walls.
Gene_expression (express) of CXCL2 in immune cells associated with chemokine and cytokine
3) Confidence 0.44 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.17 Pain Relevance 0.10
, IL-8, and CXCL2 expression, is also elevated and correlates with the reduction in forced expiratory volume in one second (FEV1) in COPD patients.7
Gene_expression (expression) of CXCL2 associated with pulmonary disease
4) Confidence 0.31 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915539 Disease Relevance 1.41 Pain Relevance 0.27
This conclusion is supported, at least in part, by the results of Sukumaran and colleagues [52], who reported the upregulated expression of chemokine genes encoding CXCL1, CXCL2, CXCL3, CXCL8, CCL3, CCL4 and CCL20 after infection of PMN with Anaplasma phagocytophilum.
Gene_expression (expression) of CXCL2 associated with chemokine and infection
5) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.58 Pain Relevance 0.50
IL33 rapidly induced the phosphorylation of MAPKs and IkappaBalpha, and enhanced the expression of inflammatory mediators (IL6, IL8, IP-10, Gro-alpha, Gro-beta and MCP-1) in IL4- or IFNgamma-pretreated cells.
Gene_expression (expression) of Gro-beta
6) Confidence 0.16 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0 Pain Relevance 0
More recently, research using MCF-7 and SKBR3 breast cancer cells showed that phenolic compounds inhibit cell growth in these cell lines in a dose dependent manner and reduce expression of the HER2 oncogene which plays a integral role in malignant transformation, tumorigenesis, and metastasis [132–134].
Gene_expression (expression) of HER2 oncogene in MCF-7 associated with malignant neoplastic disease, breast cancer and metastasis
7) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 1.14 Pain Relevance 0

General Comments

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