INT164920

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 22
Total Number 30
Disease Relevance 13.63
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL33) extracellular region (IL33)
Anatomy Link Frequency
PSCs 3
shell 1
D17 1
brainstem 1
nucleus 1
IL33 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 100.00 Very High Very High Very High
fibrosis 18 99.08 Very High Very High Very High
Chronic pancreatitis 15 99.04 Very High Very High Very High
sNRI 91 95.44 Very High Very High Very High
Duloxetine 84 95.16 Very High Very High Very High
medulla 6 93.96 High High
sSRI 98 93.68 High High
Inflammation 31 92.60 High High
depression 98 91.76 High High
chemokine 18 89.36 High High
Disease Link Frequency Relevance Heat
Infection 53 100.00 Very High Very High Very High
Disease 117 99.52 Very High Very High Very High
Liver Disease 2 99.36 Very High Very High Very High
Fibrosis 24 99.34 Very High Very High Very High
Suicidal Behaviour 14 99.16 Very High Very High Very High
Pancreatitis 15 99.04 Very High Very High Very High
Mouth Disease 390 97.52 Very High Very High Very High
Reprotox - General 3 7 97.40 Very High Very High Very High
Primary Sclerosing Cholangitis 9 96.24 Very High Very High Very High
Chronic Renal Failure 7 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Messenger RNA expression for IL33, ST2L and IL1RAcP was analysed by northern blotting and real-time PCR analyses, and protein expression was assessed by western blotting and ELISA.
Spec (analysed) Gene_expression (expression) of IL33
1) Confidence 0.76 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Gene_expression (Expression) of interleukin 33 associated with cytokine
2) Confidence 0.76 Published 2010 Journal Gut Section Title Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0.23
To define the role of IL33 in fibrogenesis of the pancreas, the expression of IL33, ST2L and IL1RAcP was examined in chronic pancreatitis tissues.
Spec (examined) Gene_expression (expression) of IL33 in pancreas associated with fibrosis and chronic pancreatitis
3) Confidence 0.76 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.20 Pain Relevance 0.18
RESULTS: IL33, ST2L and IL1RAcP were expressed by alpha-SMA-positive myofibroblasts in the fibrosis of chronic pancreatitis.
Gene_expression (expressed) of IL33
4) Confidence 0.76 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.08 Pain Relevance 0
The expression of IL33, ST2L and IL1RAcP was evaluated by standard immunohistochemical procedures.
Gene_expression (expression) of IL33
5) Confidence 0.76 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
In human pancreatic myofibroblasts, IL33 was weakly immunoexpressed without any stimuli, and this was markedly enhanced by IL1beta, tumour necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) via the mitogen-activated protein kinase (MAPK)-dependent AP-1 activation pathway.
Neg (without) Gene_expression (immunoexpressed) of IL33
6) Confidence 0.66 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.07 Pain Relevance 0
In conclusion, activated PSCs expressed IL-33 in the nucleus.
Gene_expression (expressed) of IL-33 in PSCs
7) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.22 Pain Relevance 0.08
Nuclear IL-33 expression was also observed in the pancreatic acinar and ductal cells.
Gene_expression (expression) of IL-33
8) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.39 Pain Relevance 0.15
The expression of IL-33 was examined by Western blotting, PCR, ELISA, and immunostaining.
Gene_expression (expression) of IL-33
9) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.45 Pain Relevance 0.18
Nuclear expression of interleukin-33 in pancreatic stellate cells.
Gene_expression (expression) of interleukin-33 in stellate cells
10) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 20689058 Disease Relevance 0.45 Pain Relevance 0.19
Activated PSCs expressed IL-33 in the nucleus, and the expression was increased by IL-1?
Gene_expression (expressed) of IL-33 in nucleus
11) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.42 Pain Relevance 0.16
induced IL-33 expression mainly through the activation of NF-?
Gene_expression (expression) of IL-33
12) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.38 Pain Relevance 0.14
We here examined the expression of IL-33 and the IL-33-mediated regulation of cell functions in PSCs.
Spec (examined) Gene_expression (expression) of IL-33 in PSCs
13) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.46 Pain Relevance 0.19
Decreased IL-33 expression by small interfering RNA resulted in decreased proliferation in response to PDGF-BB.
Gene_expression (expression) of IL-33
14) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.30 Pain Relevance 0.11
B and ERK pathways and partially through that of p38 MAP kinase, whereas PDGF-BB induced IL-33 expression mainly through the activation of ERK pathway.
Gene_expression (expression) of IL-33
15) Confidence 0.53 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.35 Pain Relevance 0.13
An option to enroll in a long-term open label extension study was offered to the patients who participated in three of these studies.31–33

DVS trials in doses of 100 mg/day and higher

Gene_expression (trials) of DVS
16) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0.78 Pain Relevance 0.23
Before the practicing clinician can evaluate when to prescribe DVS in the 50 to 100 mg dose range, there is clearly a need for more published “head to head” comparisons with other SNRIs (duloxetine and venlafaxine) and with SSRIs, particularly escitalopram.
Gene_expression (prescribe) of DVS in head associated with ssri, duloxetine and snri
17) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0.32 Pain Relevance 0.32
Since DVS is almost entirely excreted in urine, patients with renal impairment present a greater clinical concern.
Gene_expression (excreted) of DVS in urine
18) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0.16 Pain Relevance 0.14
The differences in HAM-D17 response and remission rates for DVS compared to placebo were not statistically significant.
Gene_expression (response) of DVS in D17
19) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0.32 Pain Relevance 0.03
Results were significantly higher for DVS 50 mg (p = 0.001) than placebo only after 1 week, and higher for DVS 100 mg (p = 0.017) only during week two, when patients switched from receiving 50 mg of DVS to no active treatment.34
Gene_expression (higher) of DVS
20) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 1.09 Pain Relevance 0.17

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