INT164925

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GIP, INS) extracellular region (GIP, INS) extracellular space (INS)
signal transduction (GIP) carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
small intestine 2
GIP (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 1 70.76 Quite High
Paracetamol 1 51.92 Quite High
tolerance 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 57 99.24 Very High Very High Very High
Hyperinsulinism 2 86.92 High High
Dyspepsia 1 70.76 Quite High
Hyperglycemia 4 10.64 Low Low
Insulin Resistance 6 7.12 Low Low
Hypoglycemia 16 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Weight Gain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secreted by K cells of the small intestine, GIP is also known to stimulate insulin secretion; individuals with type 2 diabetes appear to have a diminished response to this hormone, rather than being deficient in its production (Holst 2002; Drucker 2003).


GIP Positive_regulation (stimulate) of Localization (secretion) of insulin in small intestine associated with diabetes mellitus
1) Confidence 0.59 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.70 Pain Relevance 0
However, both insulin and GIP lower post-Intralipid FFA concentration, GIP probably via stimulation of insulin secretion, increasing FFA reesterification.
GIP Positive_regulation (stimulation) of Localization (secretion) of insulin
2) Confidence 0.43 Published 2010 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 19996386 Disease Relevance 0.16 Pain Relevance 0.09

General Comments

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