INT164975

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.38
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ELN) extracellular region (ELN) proteinaceous extracellular matrix (ELN)
Anatomy Link Frequency
angular 1
neck 1
lamella 1
papillae 1
lung 1
ELN (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 73 100.00 Very High Very High Very High
pruritus 2 92.88 High High
lumbar region 3 87.40 High High
Inflammatory response 1 80.56 Quite High
cva 4 79.40 Quite High
fibrosis 6 78.20 Quite High
Bioavailability 2 67.00 Quite High
Inflammation 25 66.00 Quite High
Bile 2 65.44 Quite High
Pain 84 60.00 Quite High
Disease Link Frequency Relevance Heat
Acrodermatitis 4 98.46 Very High Very High Very High
Anaemia 2 98.20 Very High Very High Very High
Nutritional Deficiencies 28 97.10 Very High Very High Very High
Skin Appendage Disease 12 96.12 Very High Very High Very High
Alopecia 2 95.56 Very High Very High Very High
Glossitis 2 95.12 Very High Very High Very High
Recurrence 39 94.16 High High
Eczema 10 93.56 High High
Cheilitis 2 93.48 High High
Pruritus 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dermatitis, alopecia, and nail defects are also associated with zinc deficiency.[4] Acrodermatitis enteropathica develops in a zinc-deficient patient and a combined nutritional deficiency of zinc, EFAs, albumin and amino acids may result in acrodermatitis enteropathica.[14] The activities of lysyl oxidases that initiate the cross-linking of collagen and elastin decline with copper deficiency.[15] Chronic iron deficiency has resulted in spoon shaped nails (koilonychia), hair loss, glossitis with loss of papillae, angular cheilitis, and pruritus.[4]
elastin Binding (linking) of in angular associated with skin appendage disease, glossitis, acrodermatitis, nutritional deficiencies, eczema, anaemia, pruritus, cheilitis and alopecia
1) Confidence 0.35 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2965901 Disease Relevance 2.14 Pain Relevance 0.15
In an acellular model, cigarette smoke inhibits elastin cross-linking (Laurent et al 1983), while the transcription of lysyl oxidase, a key effector of elastin cross-linking is reduced in fetal rat lung fibroblasts exposed to cigarette smoke extract (Gao et al 2005).
elastin Binding (cross) of in lung
2) Confidence 0.21 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.12 Pain Relevance 0
CONCLUSIONS: The VAS was found to have an excellent correlation in older children with acute pain in the ED and had a uniformly increasing relationship with WBS.
WBS Binding (relationship) of
3) Confidence 0.21 Published 2010 Journal Acad Emerg Med Section Body Doc Link 20003121 Disease Relevance 0 Pain Relevance 0
Dermatitis, alopecia, and nail defects are also associated with zinc deficiency.[4] Acrodermatitis enteropathica develops in a zinc-deficient patient and a combined nutritional deficiency of zinc, EFAs, albumin and amino acids may result in acrodermatitis enteropathica.[14] The activities of lysyl oxidases that initiate the cross-linking of collagen and elastin decline with copper deficiency.[15] Chronic iron deficiency has resulted in spoon shaped nails (koilonychia), hair loss, glossitis with loss of papillae, angular cheilitis, and pruritus.[4]
elastin Binding (linking) of in papillae associated with skin appendage disease, glossitis, acrodermatitis, nutritional deficiencies, eczema, anaemia, pruritus, cheilitis and alopecia
4) Confidence 0.12 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2965901 Disease Relevance 2.14 Pain Relevance 0.15
They may also bind the lamellae together as elastin fibers pass radially from one lamella to the next [16].
elastin Binding (bind) of in lamella
5) Confidence 0.04 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.08 Pain Relevance 0.11
Previously, peptide sequences similar to fibroin have been conjugated with elastin to prepare particles for the controlled delivery of naked DNA (Megeed et al 2004).
elastin Binding (conjugated) of
6) Confidence 0.02 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426758 Disease Relevance 0.83 Pain Relevance 0.13
1.0 ng/ml underwent imaging with neck ultrasound, FDG-PET and post therapy 131I WBS.
WBS Binding (underwent) of in neck associated with imagery
7) Confidence 0.02 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1950687 Disease Relevance 1.06 Pain Relevance 0.09

General Comments

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