INT164987

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.26
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mrgprx1) plasma membrane (Mrgprx1) molecular_function (Mrgprx1)
cellular_component (Mrgprx1) biological_process (Mrgprx1) signal transducer activity (Mrgprx1)
Anatomy Link Frequency
neurons 2
spinal nerve 1
brain 1
Mrgprx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 51 98.80 Very High Very High Very High
Eae 55 98.20 Very High Very High Very High
agonist 1 95.44 Very High Very High Very High
Pain 151 93.92 High High
Inflammation 47 93.84 High High
superficial lamina 3 89.08 High High
medulla 5 87.96 High High
qutenza 4 82.72 Quite High
primary afferent fibers 5 79.44 Quite High
Neuropeptide 3 78.56 Quite High
Disease Link Frequency Relevance Heat
Pruritus 13 100.00 Very High Very High Very High
Targeted Disruption 252 99.04 Very High Very High Very High
Pain 170 93.92 High High
INFLAMMATION 47 93.84 High High
Neuropathic Pain 232 74.92 Quite High
Nociception 20 73.00 Quite High
Cancer 3 63.76 Quite High
Inflammatory Pain 57 60.88 Quite High
Injury 40 60.80 Quite High
Ganglion Cysts 5 41.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is no statistical difference in the expression of MrgC11, D, F, G, H and PR4 genes in DRG of KO and WT mice.
Gene_expression (expression) of MrgC11 associated with targeted disruption
1) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 1.09 Pain Relevance 0.74
Furthermore, MrgprA3-expressing neurons respond to histamine and coexpress gastrin-releasing peptide, a peptide involved in itch sensation, and MrgprC11.
Gene_expression (coexpress) of MrgprC11 in neurons associated with pruritus
2) Confidence 0.59 Published 2009 Journal Cell Section Abstract Doc Link 20004959 Disease Relevance 0.66 Pain Relevance 0.09
Expression of rat MrgC and MrgA is down regulated in DRG following spinal nerve ligation provided additional evidence that these receptors are somehow functionally linked to pain [4].
Gene_expression (Expression) of MrgC in spinal nerve associated with pain and eae
3) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 0.62 Pain Relevance 0.72
MrgC11 and D expression was detected at extremely low levels in brain and SC preparations from some, but not all, mice while MrgPRa4 or MrgG expression was not detected in brain or SC (data not shown).
Gene_expression (expression) of MrgC11 in brain associated with spinal cord
4) Confidence 0.55 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 0.99 Pain Relevance 0.82
RNA was reverse transcribed using the GeneAmp RNA PCR kit (Applied Biosystems) and 15 ng/well equivalent of cDNA used in quantitative PCR TaqMan® to determine gene expression levels of MrgC11, D, E and G using custom oligos (Sigma) and MrgF, H and PR4 using Assays on Demand™ (Applied Biosystems).
Spec (determine) Gene_expression (levels) of MrgC11
5) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 0.32 Pain Relevance 0.29
RNA was reverse transcribed using the GeneAmp RNA PCR kit (Applied Biosystems) and 15 ng/well equivalent of cDNA used in quantitative PCR TaqMan® to determine gene expression levels of MrgC11, D, E and G using custom oligos (Sigma) and MrgF, H and PR4 using Assays on Demand™ (Applied Biosystems).
Spec (determine) Gene_expression (expression) of MrgC11
6) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 0.32 Pain Relevance 0.30
Another program B gene Mrgprc11 is expressed in both Mrgpra3+ and Mrgprb4+ neurons [24].
Gene_expression (expressed) of Mrgprc11 in neurons
7) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.20 Pain Relevance 0.14
For example, expression of several Mrgpr class GPCRs (Mrgpra3, Mrgprb4, and Mrgprc11), which was eliminated in E-CKO mice [14,24], was fully "restored" in L-CKO mice (Fig. 1C).
Gene_expression (expression) of Mrgprc11
8) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.36
Tissue preparation, the in situ hybridization (ISH) procedure, and the probes for TRPM8, TRPV1, Mrgprc11, CGRP, Mrgprd, TRPC3, P2X3, Mrgpra3, Mrgprb4, TrkA, SCG10, DRASIC, Ret, and GluR5/Grik1, have been described previously [14,24,41].
Gene_expression (probes) of Mrgprc11
9) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.06 Pain Relevance 0

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