INT165

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.76
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HRH1) plasma membrane (HRH1) nucleus (HRH1)
cytoplasm (HRH1) signal transducer activity (HRH1)
Anatomy Link Frequency
plasma 1
embryonic kidney 1
HRH1 (Homo sapiens)
HRH1 - H1112R (1) HRH1 - V1110I (1)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
Analgesic 7 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Mexiletine 6 99.98 Very High Very High Very High
agonist 4 99.96 Very High Very High Very High
nociceptor 1 99.66 Very High Very High Very High
Morphine 25 99.36 Very High Very High Very High
Antinociceptive 3 99.36 Very High Very High Very High
antinociception 18 99.20 Very High Very High Very High
dexamethasone 1 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 97.36 Very High Very High Very High
Drug Dependence 5 96.20 Very High Very High Very High
Angina 4 93.72 High High
Disease 48 88.16 High High
Hypersensitivity 3 86.16 High High
Asthma 4 85.60 High High
Generaliased Trisomy 1 81.64 Quite High
Cancer 31 78.24 Quite High
Syndrome 47 53.52 Quite High
Metastasis 1 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of H1-receptor stimulation on coronary arterial diameter and coronary hemodynamics in humans.
Regulation (Effects) of H1-receptor
1) Confidence 0.45 Published 1990 Journal Circulation Section Title Doc Link 2297849 Disease Relevance 0.18 Pain Relevance 0.18
Effects of H1-receptor stimulation on coronary arterial diameter and coronary hemodynamics were examined in 11 patients with angiographically normal coronary arteries and without variant angina or resting angina.
Regulation (Effects) of H1-receptor associated with angina
2) Confidence 0.45 Published 1990 Journal Circulation Section Abstract Doc Link 2297849 Disease Relevance 0.19 Pain Relevance 0.19
The histamine H1 antagonists mepyramine and ketotifen and the calcium antagonists verapamil, nifedipine and TMB-8 were also ineffective in suppressing FMLP-induced elastase release.
Regulation (ineffective) of histamine H1 associated with antagonist
3) Confidence 0.21 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.57 Pain Relevance 0.45
Effect of histamine receptor antagonists and indomethacin on implantation in the rabbit.
Regulation (Effect) of histamine receptor associated with antagonist
4) Confidence 0.20 Published 1983 Journal Biol. Reprod. Section Title Doc Link 6139132 Disease Relevance 0.23 Pain Relevance 0.35
To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, (mu)1, and rBII, which were transiently expressed in human embryonic kidney (HEK) 293 cells.
Regulation (sensitivity) of rH1 in embryonic kidney associated with mexiletine
5) Confidence 0.13 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11904157 Disease Relevance 0 Pain Relevance 0.49
The differential effects of histamine receptor antagonists on morphine- and U-50,488H-induced antinociception in the mouse.
Regulation (effects) of histamine receptor associated with antinociception, analgesic, antagonist and morphine
6) Confidence 0.09 Published 1994 Journal Life Sci. Section Title Doc Link 7904710 Disease Relevance 0 Pain Relevance 1.87
The effects of L-histidine, and of the specific histamine receptor agonists 2-methylhistamine and 4-methylhistamine, on the expression of morphine tolerance and physical dependence have been studied in mice.
Regulation (effects) of histamine receptor associated with physical dependence, tolerance, agonist and morphine
7) Confidence 0.01 Published 1976 Journal Agents Actions Section Abstract Doc Link 987696 Disease Relevance 0.30 Pain Relevance 0.67
The influence of histamine receptor antagonists on antinociceptive action of narcotic analgesics.
Regulation (influence) of histamine receptor associated with analgesic, antagonist and antinociceptive
8) Confidence 0.01 Published 1987 Journal Pol J Pharmacol Pharm Section Title Doc Link 2894018 Disease Relevance 0 Pain Relevance 1.67
Effects of intrathecally injected histamine receptor antagonists on the antinociception induced by morphine, beta-endorphin, and U50, 488H administered intrathecally in the mouse.
Regulation (Effects) of histamine receptor associated with antinociception, analgesic, antagonist and morphine
9) Confidence 0.00 Published 1996 Journal Neuropeptides Section Title Doc Link 8923512 Disease Relevance 0 Pain Relevance 1.50
In an attempt to detect the existence of histaminergic mechanisms in the regulation of prolactin secretion in rats, the effects of histidine and histamine-receptor antagonists (chlorpheniramine and metiamide) on plasma prolactin levels in urethan-anesthetized rats were investigated in relation to other aminergic mechanisms.
Regulation (effects) of histamine-receptor in plasma associated with antagonist
10) Confidence 0.00 Published 1976 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 14035 Disease Relevance 0 Pain Relevance 0.21
Although there is little known about human ECL-cells and the effects of NO on histamine-release there are studies that indicate species differences in other histamine-secreting cells.
Regulation (effects) of histamine-release
11) Confidence 0.00 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
kinase domain and all are missense mutations which change the amino acid

(V1110I, H1112R, H1112Y, M1149T, V1206L, V1238I, D1246N, Y1248C, Y1248D,

Regulation (change) of H1112R (V1110I, H1112R)
12) Confidence 0.00 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.30 Pain Relevance 0

General Comments

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